Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Nolan S HartkampReinoud P H Bokkers

Abstract

Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular reactivity and whether haemodynamic impairment is influenced at brain tissue level by the existence of primary and/or secondary collateral. Eighty-eight patients with steno-occlusive ICA disease and 29 healthy controls underwent MR examination. The presence of collaterals was determined with time-of-flight, two-dimensional phase contrast MRA and territorial arterial spin labeling (ASL) imaging. Cerebral blood flow and cerebrovascular reactivity were assessed with ASL before and after acetazolamide. Cerebral haemodynamics were normal in asymptomatic ICA stenosis patients, as opposed to patients with ICA occlusion, in whom the haemodynamics in both hemispheres were compromised. Haemodynamic impairment in the affected brain region was always present in symptomatic patients. The degree of collateral blood flow was inversely correlated with haemodynamic impairment. Recruitment of secondary collaterals only occurred in symptomatic ICA occlusion patients. In conclusion, both CBF and cerebr...Continue Reading

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Citations

Jul 6, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Hendrikus Antonius Rik KranenburgRoger Kerry
Jan 29, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexander SeilerMarlies Wagner
Jun 9, 2020·Translational Stroke Research·Lita von BiebersteinSusanne Wegener
Sep 28, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Doeschka A FerroChristopher Chen
Oct 4, 2020·Journal of Shoulder and Elbow Surgery·Eric W GuoEric C Makhni

Related Concepts

Acetazolamide
Brain
Carotid Arteries
Carotid Artery Diseases
Internal Carotid Artery Structure
Diagnostic Imaging
Hemodynamics
Magnetic Resonance Imaging
Occlusion of Internal Carotid Artery
Cerebral Hemisphere Structure (Body Structure)

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