Relationship between haemodynamics and morphology in pulmonary hypertension. A quantitative intravascular ultrasound study

European Heart Journal
A C BorgesF X Kleber

Abstract

Intravascular ultrasound imaging of the pulmonary arteries has been demonstrated to be a reliable method of quantifying vessel diameter, luminal area and pulsatility. Simultaneous measurement of flow velocity and its response to vasodilators allows the relationship between morphology and functional compromise to be studied, especially endothelial dysfunction. In 51 patients (mean age = 49.8 +/- 12.6 years, 17 female) we performed right heart catheterization and simultaneous intravascular ultrasound of pulmonary artery branches. The patients were divided in two groups: group 1 with normal pulmonary artery pressure and pulmonary vascular resistance, and group 2 with pulmonary hypertension (peak pulmonary artery pressure > 30 mmHg and/or mean pulmonary artery pressure > 20 mmHg). Vessel wall and lumen were studied using a 2.9 F intravascular ultrasound catheter with a 30 MHz phased array transducer. Measurement of blood flow velocity was accomplished by a Doppler flow wire (0.018 inch). The maximal flow change during acetylcholine infusion (adjusted to 10(-6); 10(-5), and 10(-4) M concentration in the blood vessel) was measured. There were no significant differences between groups 1 and 2 with respect to age (48.5 +/- 14.3 years v...Continue Reading

Citations

Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R WenselF X Kleber
Nov 18, 2015·Journal of cardiology·Elisabete JorgeMariano Pêgo
Aug 20, 2016·Journal of Clinical Monitoring and Computing·Laurent GodinasGérald Simonneau
Feb 2, 2013·Pulmonary Circulation·Lian Tian, Naomi C Chesler

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