Relationship between hairy cell leukemia variant and splenic lymphoma with villous lymphocytes: presentation of a new concept

American Journal of Hematology
T SunJ Brody

Abstract

An unusual case of low-grade B-cell lymphoproliferative disorder with peripheral lymphocytosis and splenomegaly followed for 4 1/2 years is reported. During this period, the phenotype of the tumor cells in the blood changed from that of hairy cell leukemia (HCL)/chronic lymphocyte leukemia (CLL) to HCL/prolymphocytic leukemia (PLL), to PLL. The lymphoid population in the blood showed a mixture of hairy cells, villous lymphocytes, small lymphocytes, and prolymphocytes, corresponding to the phenotypes at various stages. Although relatively specific markers for CLL, HCL, and PLL, such as CD5, CD11c, CD22, CD25, and FMC-7, were positive at various stages, all these markers have also been demonstrated in a large study series of splenic lymphoma with villous lymphocytes (SLVL). In addition, the histologic pattern of the bone marrow biopsy and splenectomy specimen were not typical for HCL. This case can therefore be classified either as HCL variant or as SLVL. As SLVL assumes various cytologic and histologic patterns, which overlap with different lymphoproliferative disorders, especially HCL variants, this entity appears to represent a heterogeneous group of lymphomas/leukemias that may evolve into each other. The absence of activatio...Continue Reading

References

Sep 1, 1990·Hematological Oncology·T SunS Teichberg
Apr 1, 1993·American Journal of Clinical Pathology·D A ArberR K Brynes

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Citations

Jun 19, 2010·Cancer Treatment Reviews·Tadeusz Robak
Nov 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J KreitmanMaryalice Stetler-Stevenson
Mar 2, 2005·Archives of Pathology & Laboratory Medicine·Charin Ya-InHong Chang

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