Relationship between hematopoietic parameters and behavioral measures in lead-exposed rats

Toxicology and Applied Pharmacology
L HastingsR Sekeres

Abstract

The effects of low level lead (Pb) exposure on learning tasks in developing rats were investigated and the results correlated with individual hematopoietic indices. Pups received exposure via the dams milk; dams were exposed to either 0-, 545-, or 1090-ppm Pb during the lactation period. At Day 30 of age, half of the high Pb group was placed on distilled water; the remaining groups continued on the same exposure regimens as their dams. On Days 20, 30, and 90, blood samples for all rats were obtained via cardiac puncture. Each sample was analyzed for Pb concentration, free erythrocyte protoporphyrin (FEPs), hematocrit, and hemoglobin. Beginning at Day 90, all rats were tested on a battery of tasks designed to investigate the following questions: (1) to what degree lead exposure interferes with reversal learning; (2) whether changing of task requirements adversely affects acquisition of a new task; (3) to what extent task difficulty contributes to lead-induced deficits; and (4) whether lead exposure affects the capacity to retain information over short or long periods of time. The actual testing paradigms included spatial discrimination with reversal, visual discrimination with reversal, and visual discrimination task with delay....Continue Reading

References

May 1, 1979·Pharmacology, Biochemistry, and Behavior·P J Bushnell, R E Bowman
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P B Hammond
Jan 1, 1979·CRC Critical Reviews in Toxicology·J D Repko, C R Corum
Jun 15, 1982·Toxicology and Applied Pharmacology·H ZenickI A Michaelson

❮ Previous
Next ❯

Citations

Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·J Burger
Jan 1, 1987·Neurotoxicology and Teratology·W R Holloway, D H Thor
May 1, 1990·Neurotoxicology and Teratology·J M DavisL D Grant
Jul 20, 2002·Neurotoxicology and Teratology·Juan A Salinas, Nicole C Huff
Jul 20, 2002·Neurotoxicology and Teratology·Juan A Salinas, Nicole C Huff
Nov 27, 1998·Neurotoxicology and Teratology·S A FergusonP H Siitonen
Apr 12, 2000·Neurotoxicology and Teratology·H GaravanB J Strupp
Jan 1, 1985·Journal of Toxicology and Environmental Health·J Burger, M Gochfeld
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Jul 25, 2019·Frontiers in Behavioral Neuroscience·Cristian Perez-FernandezFernando Sánchez-Santed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.