Relationship between histamine2-receptor antagonist medications and risk of invasive breast cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Robert W MathesChristopher I Li

Abstract

Histamine(2)-receptor antagonist (H(2) blocker) medications are used to treat heartburn, gastroesophageal reflux disease, and ulcers. Some H(2) blockers, specifically cimetidine and ranitidine, also increase serum prolactin concentrations. Given the positive relationship between prolactin levels and postmenopausal breast cancer risk, use of H(2) blockers is a potential breast cancer risk factor. The few previous studies evaluating this association have been null but have been limited by small sample sizes, and none have evaluated risk by either histologic type or estrogen receptor/progesterone receptor status. Combining data from two population-based case-control studies conducted in western Washington, we assessed the relationship between use of H(2) blockers and risk of different types of breast cancer among 1,941 cases and 1,476 controls 55 to 79 years old. Odds ratios and 95% confidence intervals (95% CI) were calculated using polytomous logistic regression. Current use of H(2) blockers overall, cimetidine, and famotidine was not associated with an increased risk of either invasive ductal or invasive lobular breast cancer. Current users of ranitidine had a 2.2-fold (95% CI, 1.1-4.3) increased risk of ductal carcinoma that w...Continue Reading

Citations

Apr 21, 2009·Metabolism: Clinical and Experimental·Jarosław von Mach-SzczypińskiMałgorzata Stanosz
Mar 20, 2016·Carcinogenesis·Teng Zeng, William A Mitch
Jun 18, 2020·European Journal of Clinical Pharmacology·Hyun Jin SongPatrick Squires
Nov 11, 2018·British Journal of Pharmacology·Noelia A MassariVanina A Medina
Feb 29, 2020·Journal of Family Medicine and Primary Care·Avik RayBalakrishnan Sadasivam
Jan 30, 2021·JAMA Network Open·C Michael White
Jun 29, 2021·JAMA : the Journal of the American Medical Association·Jeffry FlorianDavid G Strauss

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