Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection

BioMed Research International
Tao XuHongtao Wang

Abstract

Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore, to derive a more precise estimation of the association, a meta-analysis was performed. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were used to assess the strength of association between HLA-DQ polymorphism (rs2856718 and rs7453920) and HBV infection risk. A total of 11 articles were used to evaluate the effect of the two polymorphisms on risk of HBV infection. The pooled data showed that HLA-DQ rs2856718-G polymorphism showed protection against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection. The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers; further investigation on a large population and different ethnicities is warranted.

References

Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
May 1, 2007·World Journal of Gastroenterology : WJG·Rashmi SinghKhalid Khan
Dec 5, 2008·The New England Journal of Medicine·Ching-Lung Lai, Man-Fung Yuen
Mar 11, 2010·American Journal of Human Genetics·Dandan ZhangChunyu Liu
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lingmin HuZhibin Hu
Oct 29, 2013·Nature Genetics·Zhibin HuHongbing Shen
Jul 22, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Yun LiaoLanlan Wang
Oct 5, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xiaowei JiGuangwen Cao
Mar 1, 2014·Journal of Clinical and Translational Hepatology·Yong-Ping YanZhong-Shu Pu
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xia GaoDianwu Liu
Jun 1, 2016·Journal of Immunology Research·Li WangKai Wang
Mar 8, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Julieta TrinksMasashi Mizokami

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Citations

Sep 3, 2019·Frontiers in Genetics·Zhenhua ZhangMengji Lu
Dec 6, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jinghang XuZheng Zeng

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