Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma

Annals of Surgical Oncology
Seiya HattoriMototsugu Oya

Abstract

Axl, which is in the TAM family of receptor tyrosine kinases, and its ligand, growth arrest-specific gene 6 (Gas6), have been associated with worse prognoses after the surgical treatment of some types of cancers. We herein investigated the biological significance of the protein expression of Axl and Gas6 on the outcomes of patients with upper tract urothelial carcinoma (UTUC). The protein expression of Axl and Gas6 was evaluated by immunohistochemistry, and their relationships with clinicopathological features were investigated in surgical specimens obtained from 161 patients who had been surgically treated for UTUC. Axl labeling was strong in 67 of 161 (42 %) cases, while Gas6 labeling was strong in 72 of 161 (45 %) cases. The strong expression of Axl correlated with that of Gas6. A high pathological stage (p = 0.009), strong expression of Gas6 (p = 0.038), and strong expression of Axl (p = 0.016) were independent factors for predicting worse cancer-specific survival (CSS). In a subgroup analysis of patients with pT < 2 (N = 53), no significant difference in CSS was observed between patients weakly and strongly expressing Axl/Gas6. In contrast, a subgroup analysis of patients with pT ≥ 2 (N = 108) revealed that the expression ...Continue Reading

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Citations

Apr 22, 2016·World Journal of Urology·Aurélie MbeutchaShahrokh F Shariat
Nov 12, 2016·Cancers·Erinn B Rankin, Amato J Giaccia
Sep 2, 2016·Current Opinion in Urology·Solene-Florence Kammerer-JacquetKarim Bensalah
Jun 10, 2017·World Journal of Gastroenterology : WJG·Wael M Abdel-RahmanMaha Saber-Ayad
Jan 25, 2017·Oncotarget·Ghada Abboud-JarrousTal Burstyn-Cohen
Mar 6, 2017·Oncology Reports·Yun Jung ChoiJae Cheol Lee
Mar 3, 2020·Frontiers in Chemistry·Edita SarukhanyanThomas Dandekar
Jul 22, 2021·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Murat AkgülLevent Türkeri

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