Abstract
Indocyanine green retention test (ICG-r15) is a non-invasive marker of functional hepatic reserve. Among patients with compensated cirrhosis, ICG-r15 correlates to the degree of portal hypertension (PH); however, its prognostic relationship with the occurrence of decompensation events still requires clarification. ICG-r15 was prospectively measured in 154 patients with compensated cirrhosis. Patients with hepatocellular carcinoma (HCC), Child-Pugh B-C, MELD>15, bilirubin > 2 mg/dl, INR > 1.5 or portal vein thrombosis were excluded. All patients underwent laboratory tests, upper endoscopy and hepatic venous pressure gradient (HVPG). Decompensation, development of HCC, liver transplant and death were recorded and analysed through competing-risk analysis. The study group was composed of 134 patients who were followed for a median of 39 months. During follow-up, 46 patients (34.3%) developed liver decompensation. Hepatocellular carcinoma occurred in 18 patients and two patients died from non-liver-related causes. The 1-, 2- and 3-year cumulative incidences of decompensation were 9.7%, 28.4% and 33.4% respectively. Patients with ICG-r15 < 10% did not experience any decompensation events during follow-up, while the 3-year cumulative ...Continue Reading
References
Jul 1, 1993·Seminars in Surgical Oncology·M MakuuchiS Kawasaki
Apr 1, 1960·The Journal of Clinical Investigation·G R CHERRICKC S DAVIDSON
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roberto J Groszmann, Suchat Wongcharatrawee
Nov 22, 2005·Journal of Hepatology·Gennaro D'AmicoLuigi Pagliaro
Nov 25, 2005·The New England Journal of Medicine·Roberto J GroszmannUNKNOWN Portal Hypertension Collaborative Group
Oct 20, 2006·Seminars in Liver Disease·Jaime BoschJuan G Abraldes
Aug 8, 2007·Gastroenterology·Cristina RipollUNKNOWN Portal Hypertension Collaborative Group
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Dec 6, 2007·Journal of Clinical Gastroenterology·Cristina Ripoll
Feb 25, 2009·BMJ : British Medical Journal·Karel G M MoonsDouglas G Altman
Mar 24, 2009·Journal of Hepatology·Cristina RipollUNKNOWN Portal Hypertension Collaborative Group
Sep 3, 2009·Nature Reviews. Gastroenterology & Hepatology·Jaime BoschJuan Carlos García-Pagan
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Jun 29, 2010·Gut·Alexander ZipprichMatthias M Dollinger
Jul 6, 2010·The British Journal of Surgery·Y YokoyamaM Nagino
Jul 20, 2010·Journal of Hepatology·Roberto de Franchis, UNKNOWN Baveno V Faculty
Mar 1, 2011·Journal of Hepatology·Marie Angèle RobicChristophe Bureau
Jan 17, 2012·Scandinavian Journal of Gastroenterology·Cristina RipollRafael Bañares
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN European Association for Study of Liver, UNKNOWN European Organisation for Research and Treatment of Cancer
Aug 9, 2012·Scandinavian Journal of Gastroenterology·Diego RincónRafael Bañares
Sep 11, 2012·Scandinavian Journal of Gastroenterology·Francesca LodatoGiuseppe Mazzella
Sep 20, 2012·BMC Research Notes·Peter JepsenHendrik Vilstrup
Jun 19, 2013·Journal of Gastroenterology·Shintaro YamazakiMitsuhiko Moriyama
Aug 21, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghJayant A Talwalkar
Sep 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrea LisottiGiuseppe Mazzella
Feb 1, 2014·Lancet·Emmanuel A TsochatzisAndrew K Burroughs
Mar 13, 2014·Journal of Hepatology·Antonio ColecchiaDavide Festi
Mar 25, 2014·Alimentary Pharmacology & Therapeutics·G D'AmicoL Pagliaro
Apr 26, 2014·World Journal of Gastroenterology : WJG·Moon Young KimSoon Koo Baik
Oct 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marie-Louise Lindberg PindFlemming Bendtsen
Citations
Oct 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·R Todd Stravitz, Yaron Ilan
Apr 3, 2018·Journal of Digestive Diseases·Wen Ping XuWei Fen Xie
Sep 18, 2018·Journal of Gastroenterology and Hepatology·Søren MøllerFlemming Bendtsen
Dec 19, 2018·Journal of Surgical Oncology·Giovanni MarascoDavide Festi
Mar 30, 2019·Scandinavian Journal of Gastroenterology·Jon NielsenLise Borgwardt
Jul 11, 2020·Journal of the Chinese Medical Association : JCMA·Hsiao-Sheng LuMing-Chih Hou
Jun 20, 2020·Seminars in Liver Disease·Mattias MandorferThomas Reiberger
Jul 7, 2018·Gastroenterology Research and Practice·Federico RavaioliFrancesco Azzaroli
Dec 5, 2019·World Journal of Gastroenterology : WJG·Kin Pan Au, Albert Chi Yan Chan
Jul 14, 2020·World Journal of Gastroenterology : WJG·Giovanni MarascoDavide Festi
Jun 18, 2017·Investigative Radiology·Ulrika AsenbaumAndreas G Wibmer
Jan 28, 2017·World Journal of Gastroenterology : WJG·Cristina Stasi, Stefano Milani
Sep 30, 2019·Clinics in Liver Disease·Laura Turco, Guadalupe Garcia-Tsao
Mar 9, 2021·BioMed Research International·Min LiHoubao Liu
Mar 30, 2021·Hepatic Medicine : Evidence and Research·Elton DajtiFrancesco Azzaroli
Aug 25, 2021·Hepatology International·Takayuki ShimizuKeiichi Kubota