Relationship between induced sputum cytology and inflammatory status with lung structural and functional abnormalities in asbestosis

American Journal of Industrial Medicine
José Henrique SettaLuiz Eduardo Nery

Abstract

Asbestosis is associated with lung cellular and immunological abnormalities. Induced sputum cytology and local and systemic markers of inflammation may be helpful to characterize disease status and progression in these patients. Thirty-nine ex-workers with asbestosis on high-resolution CT (HRCT) and 21 non-exposed controls were evaluated. Sputum cytology and IL-8 in serum and sputum were related to lung function impairment. Subjects with asbestosis had reduced sputum cellularity but higher macrophage/neutrophil ratio and % macrophage as compared with controls. Sputum and serum IL-8 were also higher in patients with asbestosis (P < 0.05). In addition, evidence of lung architectural distorption on HRCT was associated with increased levels of serum IL-8. Interestingly, absolute macrophage number was negatively correlated with total lung capacity (r = -0.40; P = 0.04) and serum IL-8 to lung diffusing capacity (r = -0.45; P = 0.01). Occupationally exposed subjects with asbestosis on HRCT have cytologic abnormalities in induced sputum and increased local and systemic pro-inflammatory status which are correlated to functional impairment.

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Citations

Apr 23, 2010·The New England Journal of Medicine·Richard L KradinEugene J Mark
Sep 22, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kelly E DuncanRobert B Devlin
Jul 27, 2012·Respiratory Medicine·Sirpa Leivo-KorpelaEeva Moilanen
Mar 28, 2009·Current Opinion in Allergy and Clinical Immunology·Elizabeth Fireman
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology

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