Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis

Neurology
N RichertH F McFarland

Abstract

To investigate the temporal relationship between inflammation and cerebral atrophy in a longitudinal study of 19 patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly contrast enhanced MRI examinations and monthly measurements of brain fractional volume (BFV) for an average of 4 (range 2.4 to 10) years. In this retrospective study, all patients had an active MRI scan at entry with a minimum of two new contrast enhancing lesions (CEL) on baseline MRI examinations. Patients were followed for a minimum of 3 months during a baseline (pretreatment) phase and subsequently followed during treatment with recombinant interferon beta (IFN) and various other immunomodulatory agents. Pre- and post contrast axial images were obtained using 3-mm slice thickness and a gadolinium contrast dose of 0.1 mmol/kg. Monthly CEL were sequentially numbered on hardcopy films and monthly BFV was determined on precontrast T1W images using a semiautomated program. For BFV measurements, all T1W scans were registered to the entry examination, which served as a mask image. Cerebral atrophy was measured as percent brain fractional volume change (PBVC) compared to the entry baseline scan. The results demonstrate that cerebral atrophy ...Continue Reading

Citations

Feb 21, 2008·Neuromolecular Medicine·Andrei BlokhinBernadette Kalman
Sep 25, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Bibiana BielekovaRoland Martin
May 23, 2013·BMC Neurology·Roberto De MasiAntonella De Donno
Nov 15, 2011·Neurology·B BielekovaG Blevins
May 3, 2008·Current Opinion in Neurology·Paul S Giacomini, Douglas L Arnold
May 12, 2007·Journal of Neuroimmunology·Bernadette KalmanSamuel Komoly
Apr 9, 2008·Arquivos de neuro-psiquiatria·Ailton MeloAmit Bar-Or
May 8, 2007·Multiple Sclerosis : Clinical and Laboratory Research·M RovarisUNKNOWN European/Canadian Glatiramer Acetate Study Group
Nov 7, 2008·Multiple Sclerosis : Clinical and Laboratory Research·G TedeschiB Alfano
Feb 7, 2009·Journal of Geriatric Psychiatry and Neurology·Bernhard T BauneKlaus Berger
Apr 18, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Irene M VavasourAnthony Traboulsee
Jan 16, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Angela Vidal-JordanaXavier Montalban
May 4, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Tomas Kalincik
May 12, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Robert ZivadinovUNKNOWN MS-MRIUS investigators

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