Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria.

American Journal of Hematology
Gregory C DavenportDouglas J Perkins

Abstract

Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater risk of developing severe anemia (hemoglobin, Hb <6.0 g dL⁻¹) during acute malaria. However, enhanced severity of anemia was unrelated to either erythropoietic suppression or parasite-driven red blood cell hemolysis. To further explore mechanisms of anemia, circulating inflammatory mediators (IMs) were determined using a 25-plex bead array in P. falciparum-infected (Pf[+]) children (3-36 month, n = 194) stratified into three groups: HIV-1 negative (HIV-1[-]/Pf[+]); HIV-1 exposed (HIV-1[exp]/Pf[+]); and HIV-1 infected (HIV-1[+]/Pf[+]). IL-12, MIG/CXCL9, eotaxin/CCL11, and GM-CSF differed significantly and progressively increased across the groups (HIV-1[-]→HIV-1[exp]→HIV-1[+]). To further explore the relationship between the inflammatory milieu (i.e., cytokines, chemokines, and growth factors) and HIV-1 status, the large panel of IMs was reduced into discrete groups by principal component factor analysis. Of the six principal components that emerged, three components were significantly higher in the HIV-1 [+...Continue Reading

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Citations

Oct 10, 2015·British Journal of Haematology·Prakash Vishnu, David M Aboulafia
Jun 19, 2013·Immunological Reviews·Christina C ChangSharon R Lewin
Jun 30, 2015·Parasite Immunology·C G MatarA M Moormann
Dec 17, 2014·Cytokine & Growth Factor Reviews·Katrien Van RaemdonckSofie Struyf
Dec 3, 2014·Parasitology International·Jane Nchangnwi CheBrowne Chukwudi Okonkwo

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