Relationship between insulin and sex hormone-binding globulin levels during weight loss in obese women

Annals of Nutrition & Metabolism
Fulya AkinBunyamin Kaptanoglu

Abstract

The aim of this study was to assess the impact of insulin sensitivity on the relationship between sex hormone-binding globulin (SHBG) and insulin levels during active weight loss in euthyroid obese women. The study population comprised 80 premenopausal overweight and obese (BMI > or =27) women (mean age 41.44 +/- 10.03 years). Seventy patients were considered eligible for the study. Hypocaloric diets were given to all patients. Of 70 subjects who were initially willing to participate in the study, only 64 continued through to the last stage of the study. Anthropometric parameters, metabolic markers and sex hormone status were measured at baseline and on completion of the 12-week study period. Following the diet, significant decreases in insulin, homeostasis model assessment (HOMA) for insulin resistance and fasting glucose were noted. However, HOMA insulin secretion values did not change significantly. Interestingly, there was no significant correlation between SHBG and insulin levels at baseline. After weight loss, SHBG concentrations were significantly and negatively correlated with insulin levels. Therefore, it was concluded that, in severe insulin resistance, insulin does not inhibit the SHBG level. These findings could be ...Continue Reading

References

Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
Nov 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·S FranksM J Reed
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M PugeatJ Tourniaire
Jan 1, 1991·Metabolism: Clinical and Experimental·R PasqualiL Bortoluzzi
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S R PlymateK E Friedl
Jul 1, 1988·Metabolism: Clinical and Experimental·S M HaffnerJ F Dunn
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D J EvansA H Kissebah
Oct 1, 1994·Physiological Reviews·A H Kissebah, G R Krakower
Feb 1, 1993·The Journal of Clinical Endocrinology and Metabolism·J E Nestler
Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·S M HaffnerM Laakso
Dec 9, 1997·Fertility and Sterility·H F Escobar-MorrealeJ M Sancho
Sep 16, 1999·The Journal of Clinical Endocrinology and Metabolism·J M Fernández-RealW Ricart
Dec 21, 2000·Current Atherosclerosis Reports·P H Jones
Mar 15, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Tchernof, J P Després
May 3, 2001·The New England Journal of Medicine·J TuomilehtoFinnish Diabetes Prevention Study Group
Mar 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A TolinoC L De Falco
Oct 6, 2006·Obesity·Rexford S Ahima
Oct 10, 2006·Diabetes, Obesity & Metabolism·Marcelo L G Correia, Kamal Rahmouni

Citations

Jul 8, 2011·Diabetes, Obesity & Metabolism·T Byers, R L Sedjo
Aug 7, 2009·Cancer Prevention Research·Kai Ren OngAnthony Howell

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.