Relationship between insulin resistance and some coagulation and fibrinolytic parameters in patients with metabolic syndrome

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
Amany RagabOmayma Saleh

Abstract

Insulin resistance syndrome has been shown to be associated with many coagulation and fibrinolytic proteins, and these associations suggest that some coagulation and fibrinolytic proteins have a role in atherothrombotic disorders. This study was conducted to determine the levels of some of the hemostatic parameters in subjects having metabolic syndrome and to correlate these values with the anthropometric and metabolic variables associated with this syndrome. The participants were 46 obese nondiabetic subjects, 28 (group 1) who fulfilled the Adult Treatment Panel III criteria of the metabolic syndrome and 18 (group 2) who did not have metabolic syndrome, and a control group of 14 lean subjects (group 3) of matched age and sex. Clinical and laboratory evaluation of the study groups focused on anthropometric measurements (weight, height, body mass index, waist circumference, and sagittal abdominal diameter), blood pressure, and laboratory measurements of fasting plasma glucose, fasting insulin, serum lipids, tissue plasminogen activator (t-PA), antithrombin III activity (AT III), protein C, and von Willebrand factor (vWf) antigen. We observed significant increase in the concentrations of t-PA and vWf antigens in subjects having m...Continue Reading

Citations

Feb 28, 2016·The Journal of International Medical Research·Kensuke YoshidaMasami Murakami
Jan 1, 2013·Journal of Endourology·Hsiang-ying LeeYung-Shun Juan
Sep 21, 2012·Expert Review of Hematology·Claudio AnnaloroGiorgio Lambertenghi Deliliers
Aug 30, 2008·International Journal of Laboratory Hematology·E Maurer-SpurejK Chipperfield
Mar 7, 2021·Scientific Reports·Abu Saleh Md MoinStephen L Atkin

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