PMID: 7007804Feb 1, 1981Paper

Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man

Metabolism: Clinical and Experimental
T A TobeyG M Reaven

Abstract

We have previously postulated that resistance to insulin-mediated glucose uptake was the basic metabolic abnormality in patients with endogenous hypertriglyceridemia. In this situation, glucose tolerance would tend to deteriorate, and could only be maintained by the increased secretion of insulin. Although the ensuing hyperinsulinemia might prevent the development of glucose intolerance, we suggested that it would also lead to increased hepatic very low density (VLDL) triglyceride (TG) synthesis and secretion. In the current study we have quantified these four metabolic variables in 16 nonobese human subjects with plasma TG concentrations less than 175 mg/dl. The results demonstrate the following degree of correlation: insulin resistance (Formula: see text) insulin response to food (Formula: see text) VLDL-TG secretion rate (Formula: see text) plasma TG concentration. These data indicate that nonobese subjects with normal TG levels have the same relationship between degree of insulin sensitivity, insulin response to food, VLDL-TG secretion, and TG concentration previously described in patients with endogenous hypertriglyceridemia.

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Citations

Sep 1, 1991·Diabetes/metabolism Reviews·Y D Chen, G M Reaven
Dec 1, 1992·Diabetes/metabolism Reviews·K O'Dea
Jan 1, 1994·Journal of Clinical Laboratory Analysis·I J Alosachie, P M Lad
May 28, 2008·Diabetologia·A S T BickertonK N Frayn
Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·T PelikánováJ Válek
May 9, 1992·Lancet·F S FacchiniG M Reaven
Feb 1, 1995·Journal of the American College of Cardiology·M ShimabukuroN Takasu
Aug 22, 1987·Lancet·G M Reaven, B B Hoffman
Jun 17, 1998·Journal of the American College of Cardiology·I YokoyamaM Omata
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·A Hamsten
Oct 1, 1993·Baillière's Clinical Endocrinology and Metabolism·A Laws, G M Reaven
Apr 16, 1998·European Journal of Clinical Investigation·A Dembińska-KiećI Leszczyńska-Gołabek
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Michael H Davidson, H Daniel Yannicelli
Jun 1, 1991·European Journal of Clinical Investigation·E FerranniniJ K Patterson
May 1, 1994·European Journal of Clinical Investigation·R VettorG Federspil
Jun 14, 1993·Annals of the New York Academy of Sciences·T PelikánováJ Base
Sep 1, 1991·Equine Veterinary Journal·T D WatsonJ Shepherd
Mar 1, 1983·The Journal of Clinical Investigation·A H KissebahP W Adams
Jan 26, 2011·Lipids in Health and Disease·Danshan HuangAnthony P Heaney

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