PMID: 6539208Apr 1, 1984Paper

Relationship between intercellular communication and radiosensitivity of human tumor xenografts

European Journal of Cancer & Clinical Oncology
H DertingerE P Malaise

Abstract

Micro-electrode techniques permit the detection of electrical coupling between adjacent cells if they are connected by intercellular junctions (gap junctions). This technique was applied to four human tumors xenografted onto nude mice. In three of the tumors, which showed a 'contact resistance' after irradiation in vivo, electrical coupling could be established. No coupling was found in the other tumor, which did not exhibit contact resistance. These results are similar to those obtained recently with cultured spheroids of mammalian cell lines in which only the electrically coupled cell types developed contact resistance to ionizing radiation.

References

Feb 4, 1979·Biochimica Et Biophysica Acta·W R Loewenstein
Jul 1, 1973·Experimental Cell Research·D F Hülser, D J Webb
Jan 1, 1973·Physics in Medicine and Biology·K H Chadwick, H P Leenhouts
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Jan 1, 1982·Biophysics of Structure and Mechanism·H DertingerK H Jakobs
Jan 1, 1981·Radiation and Environmental Biophysics·H Dertinger, D Hülser

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Citations

Jan 1, 1982·Biophysics of Structure and Mechanism·H DertingerK H Jakobs
Jun 1, 1994·Cancer Metastasis Reviews·P L Olive, R E Durand
Jan 1, 1983·Radiation and Environmental Biophysics·H DertingerE P Malaise
Sep 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R T MulcahyR A Cooper
Jan 1, 1986·Acta Radiologica. Oncology·E K Rofstad
Oct 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E K Rofstad, R M Sutherland
May 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E K Rofstad, T Brustad
Feb 14, 2006·Theoretical Biology & Medical Modelling·Benjamin RibbaSantiago Schnell
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·W Mueller-Klieser
Nov 12, 1985·Biochimica Et Biophysica Acta·G V Vitkauskas, E S Canellakis

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