PMID: 16647016May 2, 2006Paper

Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Ye-sheng WeiJing-sheng Lan

Abstract

To study the relationship between interleukin-6 (IL-6) gene promoter-572 C/G and -634 C/G polymorphism and coronary heart disease (CHD) and the influence of IL-6 gene polymorphism on plasma lipid and lipoprotein levels. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL-6 genotype in 165 patients with CHD and 170 healthy persons. The plasma lipid and lipoprotein levels were measured by routine method. Plasma total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the patients with CHD were significantly higher than those of the controls (all P<0.05). The distributions of IL-6 gene -634 C/G polymorphism were not different between CHD group and control group (P>0.05), but the IL-6 gene-572 C/G polymorphism was significantly different between them (P<0.05). The relative risk of CHD of C allele was 1.652 times to the G allele [odds ratio (OR)=1.652, 95% confidence interval (CI): 1.137-2.401]. The level of plasma lipid in G allele carriers was significantly higher than non-carriers (P<0.05). IL-6 gene -572 C/G polymorphism is associated with CHD, and G allele is an important genetic marker. IL-6 gene polymorphism may affect CHD through e...Continue Reading

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