PMID: 8961381Jan 1, 1996Paper

Relationship between interleukin-8 and neutrophil adhesion molecules in rheumatoid arthritis

Rheumatology International
C M De GendtW J Stevens

Abstract

To evaluate the role of interleukin-8 (IL-8) on the activation of neutrophils in rheumatoid arthritis (RA), we measured IL-8 and the adhesion molecules, L-selectin (CD62L), CD1 1b and CD18, on neutrophils in paired peripheral blood and synovial fluid of RA patients. Synovial fluid IL-8 levels were significantly increased compared to peripheral blood. L-selectin was split off and CD1 1b and CD 18 were upregulated on neutrophils in the synovial fluid. A positive correlation occurred between the IL-8 concentration and CD18 or CD1 1b densities on neutrophils in the synovial fluid (r = 0.75, P < 0.005 and r = 0.60, P < 0.05, respectively). Peripheral blood neutrophils of the patients were desensitised with IL-8 in vivo, as shown by the significantly lower L-selectin shedding after in vitro IL-8 stimulation: 1.6 times decrease for patients vs 3.2 for controls (P < 0.05). In conclusion, these results add further evidence for the role of IL-8 in the activation of neutrophils in RA.

References

Mar 1, 1992·Immunology Today·G A ZimmermanT M McIntyre
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Citations

Dec 4, 1998·Springer Seminars in Immunopathology·Z SzekaneczA E Koch
Dec 24, 2002·Seminars in Immunology·Zoltán SzekaneczAlisa E Koch
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·R M SeguraT Fernández de Sevilla
Jun 4, 2013·Vascular Cell·Nicola MaruottiDomenico Ribatti
Jan 13, 2011·Experimental Cell Research·Dayanidhi RamanAnn Richmond
Nov 6, 2002·Journal of Cellular and Molecular Medicine·Edit BodolayZoltan Szekanecz

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