PMID: 15353862Sep 9, 2004Paper

Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
T TanakaZ Itoh

Abstract

5-hydroxytryptamine (5-HT) is released into the intestinal lumen during the fasting state. However, the relationship between the intraduodenal 5-HT and the interdigestive cyclic motor activity in conscious dogs is unclear. To correlate intraduodenal 5-HT concentrations with the interdigestive gastroduodenal migrating motor complex (MMC). 6 dogs were implanted with 2 force transducers for recording gastroduodenal contractions and 2 catheters for measuring duodenal volume by a non-absorbable marker perfusion technique. Intraduodenal 5-HT concentrations were determined by high performance liquid chromatography at 5-min intervals. During fasting, gastroduodenal motor activity cycled as the MMC; luminal 5-HT concentrations and total outputs varied cyclically in temporal association with the MMC. Mean 5-HT concentrations peaked during phase II (P<0.05 vs. phase I and III), and 5-HT outputs during phases II or III were greater than during phase I (P<0.05). Exogenous motilin (0.3 microg/kg-hr, IV) stimulated 5-HT release into the duodenal lumen with peak values (P<0.05) during motilin-induced phase II and III. Gastroduodenal motor activity was not altered, however, during exogenous intraduodenal administration of 5-HT (300 ng/mL-min). ...Continue Reading

References

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Citations

Oct 27, 2012·Biogerontology·Sara FidalgoShona H Wood
May 1, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Tomoko NakayoshiKatsuhiko Yanaga
Mar 28, 2012·Nature Reviews. Gastroenterology & Hepatology·Eveline DelooseJan Tack
Jul 28, 2012·Journal of Neurogastroenterology and Motility·Toku Takahashi
Dec 25, 2009·Journal of Gastroenterology·Hitoshi NakajimaToku Takahashi
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Tomoko NakayoshiKatsuhiko Yanaga
Sep 9, 2006·The Journal of Physiology·Paul P Bertrand
Jan 6, 2011·Basic & Clinical Pharmacology & Toxicology·Mark B HansenHans Gregersen
Mar 5, 2016·Journal of Neurochemistry·Peter ThornDamien J Keating
Mar 24, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Richard L YoungDamien J Keating
Jan 1, 2013·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Toku Takahashi

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