PMID: 6112782Apr 1, 1981Paper

Relationship between intravenous ethanol, alcohol-induced inhibition of pancreatic secretion and plasma concentration of immunoreactive pancreatic polypeptide, vasoactive intestinal peptide, and somatostatin in man

Regulatory Peptides
J L StaubP Vague

Abstract

We have studied in seven men, consuming less than 50 g alcohol daily, the effect of intravenous (i.v.) ethanol on (a) hormonally (secretin + CCK PZ) submaximally stimulated pancreatic secretion and (b) blood levels of pancreatic polypeptide (PP), vasoactive intestinal peptide (VIP) and somatostatin. After intravenous ethanol (600 mg/kg), pancreatic secretion decreased in all subjects and plasma levels of PP and VIP increased significantly. Moreover, there was a significant correlation between the mean inhibition of chymotrypsin output and the mean increase in PP plasma levels during the first 45 min following ethanol infusion. Therefore i.v. infusion of alcohol elicits release of PP and VIP and PP release could explain in part at least the alcohol-induced pancreatic inhibition observed in non-alcoholic men.

References

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Citations

Dec 1, 1983·Digestive Diseases and Sciences·K KubotaH Sarles
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·P J KulkoskyM A Foderaro
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·P J Kulkosky
Apr 1, 1983·Regulatory Peptides·M V SingerH Goebell
Jun 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·I de DiosM A Manso
Oct 25, 2003·Pancreas·Ashok K Saluja, Lakshmi Bhagat
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·E Niebergall-RothM V Singer
Jun 1, 1993·Gut·S ChariM V Singer
Sep 1, 1982·Scandinavian Journal of Gastroenterology·D N SchmidtH Sarles

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