Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta-analysis

Head & Neck
Joon-Hyop LeeSue K Park

Abstract

Iodine excess has been suggested as an exogenous risk factor of papillary thyroid cancer (PTC). We performed a systematic review and meta-analysis to assess the relationship between iodine exposure measured in various forms and PTC prevalence. We searched MEDLINE, Embase, and the Cochrane Library for case-control studies on iodine and PTC published up to December 2015. Exposure to iodine was compared between PTC and control groups. From the 16 selected studies, the odds ratio (OR) for the overall effect size between high iodine exposure and PTC risk was 1.418 (95% confidence interval [CI] 1.054-1.909). Based on 7 studies conducted in high iodinated regions, a positive association between iodine exposure and PTC was observed (OR 2.200; 95% CI 1.389-3.483). This study demonstrated a higher exposure to iodine in patients with PTC compared with controls, especially for patients from high iodinated regions.

References

Sep 1, 1989·International Journal of Epidemiology·S FranceschiC La Vecchia
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 1, 1994·The British Journal of Nutrition·S M LeeP R Lawrance
Oct 1, 1993·American Journal of Epidemiology·G WingrenO Axelson
Jan 3, 1996·International Journal of Cancer. Journal International Du Cancer·B PetterssonH O Adami
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 13, 2000·International Journal of Cancer. Journal International Du Cancer·A TavaniE Negri
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·U Feldt-Rasmussen
Jul 18, 2001·Cancer Causes & Control : CCC·C BosettiC La Vecchia
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Anjum MemonAjitha Suresh
Mar 28, 2002·Thyroid : Official Journal of the American Thyroid Association·John R Burgess
Aug 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I MarkakiA Linos
Apr 8, 2004·Thyroid : Official Journal of the American Thyroid Association·Jamshid FarahatiChristoph Reiners
Aug 5, 2006·Clinical Endocrinology·Thomas SehestedtChristoffer Johansen
May 10, 2007·The Journal of Clinical Endocrinology and Metabolism·C DuranteD Russo
Oct 27, 2007·The British Journal of Nutrition·Stig AndersenPeter Laurberg
Aug 13, 2008·Endocrine Pathology·H Rubén Harach, Gustavo A Ceballos
Feb 5, 2009·The Journal of Clinical Endocrinology and Metabolism·Haixia GuanMingzhao Xing
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsey EnewoldSusan S Devesa
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Pernille VejbjergTorben Jørgensen
Jan 28, 2012·Thyroid : Official Journal of the American Thyroid Association·Énora CléroFlorent de Vathaire
Feb 18, 2012·International Journal of Cancer. Journal International Du Cancer·M BlombergS K Kjaer
Mar 1, 2012·Postȩpy higieny i medycyny doświadczalnej·Elwira Przybylik-MazurekDorota Pach
Mar 2, 2012·The Journal of Nutrition·Maria AnderssonMichael B Zimmermann
Mar 15, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Takehiro MichikawaUNKNOWN Japan Public Health Center-based Prospective Study Group
Oct 6, 2012·Nutrition Reviews·Michael B Zimmermann, Maria Andersson
Jan 15, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wenwu DongYongfeng Liu
Jun 6, 2013·Journal of Cancer Epidemiology·Gabriella PellegritiRiccardo Vigneri
Aug 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fang WangWenjuan Zhao
Sep 27, 2014·Nutrition and Cancer·Zhi-Ting Liu, Ai-Hua Lin
Nov 6, 2014·The New England Journal of Medicine·Hyeong Sik AhnH Gilbert Welch
May 23, 2015·Nutrition and Cancer·Young Ae Cho, Jeongseon Kim
May 27, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Chaochen WangUNKNOWN JACC Study Group
Aug 19, 2016·The American Journal of Clinical Nutrition·WenYen JuanSuzanne P Murphy

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Citations

Mar 21, 2019·Annals of the New York Academy of Sciences·Jessica FarebrotherMaria Andersson
Oct 22, 2020·Scientific Reports·Joon-Hyop LeeKa Hee Yi
Feb 3, 2021·International Journal of Cancer. Journal International Du Cancer·Thérèse TruongFlorent de Vathaire
May 26, 2021·Endocrinology and Metabolism·Joon-Hyop LeeKa Hee Yi

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