Relationship Between L-DOPA-Induced Reduction in Motor and Exploratory Activity and Striatal Dopamine D2 Receptor Binding in the Rat

Frontiers in Behavioral Neuroscience
Susanne NikolausHans-Wilhelm Müller

Abstract

The present study assessed the influence of L-DOPA administration on neostriatal dopamine (DA) D2 receptor binding in relation to motor and exploratory behaviors in the rat. D2 receptor binding was measured in baseline, after challenge with the aromatic L-amino acid decarboxylase inhibitor benserazide, and after challenge with either 5 or 10 mg/kg L-DOPA plus benserazide. Additional rats received injections of saline. For baseline and challenges, striatal equilibrium ratios (V[Formula: see text]) were computed as estimation of the binding potential. Motor and exploratory behaviors were assessed for 30 min in an open field prior to administration of [(123)I]IBZM. D2 receptor binding was measured with small animal SPECT 2 h after radioligand administration for 60 min. Both L-DOPA doses significantly reduced D2 receptor binding relative to baseline and led to significantly less ambulation, less head-shoulder motility, and more sitting relative to saline. Moreover, 10 mg/kg L-DOPA induced less head-shoulder motility, more sitting, and more grooming than 5 mg/kg L-DOPA. Analysis of time-behavior curves showed that L-DOPA-treated animals relative to saline exhibited a faster rate of decrease of ambulation frequency and a slower rate ...Continue Reading

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Jan 8, 2015·Frontiers in Behavioral Neuroscience·Susanne NikolausHans-Wilhelm Müller

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Citations

Dec 26, 2016·Pharmacology, Biochemistry, and Behavior·Susanne NikolausHubertus Hautzel
Apr 3, 2020·PloS One·Juliane RudeckLars Lewejohann
Aug 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Yuan-Yang LaiJerome M Siegel
Mar 30, 2018·Frontiers in Behavioral Neuroscience·Susanne NikolausHubertus Hautzel
Aug 31, 2021·Frontiers in Neuroscience·Susanne NikolausHans-Wilhelm Müller

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Software Mentioned

GraphPad Prism
TierSPECT
PMOD
SPSS Statistics
SPSS
SigmaStat
GraphPad
EthoVision XT

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