Relationship Between Leptin Level, Inflammation, and Volume Status in Maintenance Hemodialysis Patients

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Ivona RisovićJasna Trbojević-Stanković

Abstract

Maintenance hemodialysis (HD) patients often experience fluctuations of volume status. Although hypervolemia possibly induces systemic inflammation, the relationship between volume status and leptin has not yet been well defined. The aims of this study were to determine the levels of leptin, C-reactive protein (CRP), and ferritin in relation to volume status and to assess the relationship between leptin and volume and inflammatory status in chronic HD patients. This prospective study included 93 HD patients divided, based on evaluation using the body composition monitor, into normovolemic and hypervolemic groups (overhydration/extracellular water [OH/ECW] ≤ 15% and OH/ECW > 15%, respectively). The levels of leptin and inflammatory markers (CRP, ferritin) were determined during a mid-week dialysis session in all patients. There were more hypervolemic patients after 12 months of follow up than at baseline (41% vs. 38%). Hypervolemic patients had significantly lower leptin levels (11.42 ± 19.24 ng/mL vs. 34.53 ± 40.32 ng/mL at baseline and 13.41 ± 22.04 ng/mL vs. 41.54 ± 21.78 ng/mL at 12 months), longer time on dialysis, and poorer nutritional status than normovolemic patients. Inflammation was present regardless of the volume st...Continue Reading

References

Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Rosa JofréRafael Pérez-Garcia
Jun 19, 2008·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Erkan DervisogluCigdem Caglayan
Jan 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Volker WizemannDaniele Marcelli
Jan 20, 2010·Annals of Internal Medicine·Theodore KelesidisChristos S Mantzoros
Jan 23, 2013·São Paulo Medical Journal = Revista Paulista De Medicina·Cynthia Mauro Piratelli, Rodolpho Telarolli Junior
Aug 15, 2014·The Journal of Endocrinology·Jeffrey Friedman
Oct 3, 2015·Iranian Red Crescent Medical Journal·Farzaneh MontazerifarMahla Pourmofatteh
Sep 15, 2017·Contributions to Nephrology·Magdalena JankowskaPeter Stenvinkel

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Citations

Feb 6, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Ivona RisovicGabrijela Malešević

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