Relationship between levels of Clostridium difficile toxin A and toxin B and cecal lesions in gnotobiotic mice.

Infection and Immunity
A VernetA L Parodi

Abstract

Various Clostridium difficile strains were studied with respect to their pathogenicity in monoassociated mice in relation to levels of toxin A and toxin B in vivo and in vitro. Two strains which were the most potent toxin producers in vitro induced mortality (100%); mice monoassociated with these strains were found to have high levels of both toxins in their ceca and an intense cecal epithelial ulceration together with a severe inflammatory process. No mortality was observed with the other strains. Strains which were moderately toxinogenic in vitro induced inflammation of the cecum but no ulceration, and no toxin A was found. Inflammation intensity was not related to toxin B levels. After 3 weeks, ceca returned to normal in spite of a chronic cytotoxin production. When compared with in vitro results, which showed a good correlation between the levels of the two toxins, toxin A amounts in vivo were found to be lowered relative to toxin B levels. The lack of detectable toxin A levels in animals infected with all but the two most highly toxinogenic strains prevented death. This work points out the importance of investigation of toxin A for the understanding of C. difficile pathogenicity.

References

May 20, 1978·Lancet·H E LarsonS P Borriello
Mar 9, 1978·The New England Journal of Medicine·J G BartlettA B Onderdonk
Mar 18, 1978·British Medical Journal·R H GeorgeD W Burdon
Mar 1, 1986·The Journal of Infectious Diseases·K H WilsonD Lyerly
Feb 1, 1985·Infection and Immunity·D M LyerlyT D Wilkins
Jan 1, 1983·Journal of Clinical Microbiology·D M LyerlyT D Wilkins
Sep 1, 1983·The Journal of Infectious Diseases·J M LibbyT D Wilkins
Mar 1, 1983·Infection and Immunity·C J CzuprynskiT Wilkins
Dec 1, 1981·Infection and Immunity·N S TaylorJ G Bartlett
Apr 1, 1980·Infection and Immunity·A B OnderdonkJ G Bartlett

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Citations

Oct 7, 2010·Digestive Diseases and Sciences·Marwan S Abougergi, John H Kwon
Oct 6, 2007·The Journal of Veterinary Medical Science·Akihiro KawanoSatoru Matsushita
Apr 1, 1993·European Journal of Pediatrics·A CollignonG Corthier
Jan 12, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Marwan S AbougergiBernard G Jaar
Jul 1, 1993·Clinical Microbiology Reviews·F C KnoopI C Crocker

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