PMID: 3762235Sep 1, 1986Paper

Relationship between life expectancy, endogenous antioxidants and products of oxygen free radical reactions in the housefly, Musca domestica

Mechanisms of Ageing and Development
R S SohalR G Allen

Abstract

The general objective of this study was to identify biochemical correlates of life expectancy in the adult male housefly. All houseflies lose flying ability prior to death, whereby, in an aging population, shorter-lived flies can be identified as flightless 'crawlers' from their longer-lived cohorts, the 'fliers'; the average lifespan of crawlers is about one-third shorter than the fliers. Neither crawlers nor fliers exhibited any physical damage to their chemoreceptive tarsi, thereby ruling out starvation as a probable cause of death. Levels of antioxidant defenses (superoxide dismutase, catalase and glutathione) and products of oxygen free radical reactions (inorganic peroxides and thiobarbituric acid [TBA]-reactants) were compared between crawlers and fliers. The fliers showed higher superoxide dismutase and catalase activities and glutathione concentration than crawlers, whereas, the amount of inorganic peroxides (H2O2) and TBA-reactants was higher in the crawlers than in fliers. Results of this study demonstrate, for the first time, that longer life expectancy of organisms belonging to the same cohort group is associated with relatively higher levels of antioxidants and lower concentrations of products of oxygen free radic...Continue Reading

References

May 1, 1977·Analytical Biochemistry·H P Misra, I Fridovich
Jan 1, 1979·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J Smith, A Shrift
May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jan 1, 1975·Experimental Gerontology·S S Ragland, R S Sohal
Oct 14, 1985·Mechanisms of Ageing and Development·R S SohalR K Newton
Mar 1, 1985·Mechanisms of Ageing and Development·R S SohalH Sies
Jun 1, 1973·Experimental Gerontology·S S Ragland, R S Sohal
Jun 1, 1981·Mechanisms of Ageing and Development·R S SohalE R Biehl
Jan 1, 1965·Archives of Biochemistry and Biophysics·R S HOLMES, C J MASTERS

❮ Previous
Next ❯

Citations

Apr 8, 2009·Biogerontology·Pamela Boon Li PunBarry Halliwell
Sep 30, 1987·Mechanisms of Ageing and Development·R S SohalR G Allen
Apr 30, 1990·Mechanisms of Ageing and Development·R S SohalU T Brunk
Mar 1, 1990·Mechanisms of Ageing and Development·H IschiropoulosY Kikkawa
Jul 1, 1987·Archives of Gerontology and Geriatrics·R S SohalK J Farmer
Jan 1, 1988·Experimental Gerontology·R ArkingR Pretzlaff
Jan 1, 1988·Experimental Gerontology·R J Shmookler Reis
Jan 1, 1990·Experimental Gerontology·R S Sohal, R G Allen
Jan 1, 1991·Free Radical Biology & Medicine·L Frank
Feb 1, 1995·Free Radical Biology & Medicine·D Darr, I Fridovich
Feb 1, 1995·Mutation Research·J RemacleG Rao
Nov 24, 2001·Respiration Physiology·A P Wickens
Dec 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aleksandra TrifunovicNils-Göran Larsson
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R S SohalW C Orr
Nov 21, 1992·Annals of the New York Academy of Sciences·R S Sohal, W C Orr
Jul 5, 1996·Science·R S Sohal, R Weindruch
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·L J YanR S Sohal
Aug 1, 1989·Journal of the American Geriatrics Society·R Arking, S P Dudas
Oct 11, 2005·Free Radical Biology & Medicine·Niels B J VollaardChris E Cooper
Jul 30, 2004·Biochimica Et Biophysica Acta·Eric Dufour, Nils-Göran Larsson
Jul 29, 2004·Clinical Science·Mikhail F AlexeyevGlenn L Wilson
Jan 1, 1991·Annals of the New York Academy of Sciences·W Regelson, R Franson
Oct 16, 2009·Ecotoxicology and Environmental Safety·Shu-Feng HuangFang-Fang Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.