Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae

Medical Oncology
Keisuke KosumiHideo Baba

Abstract

The DNA methylation alterations occurring in human cancers have two types: global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Recently, to assess global DNA methylation, long interspersed nucleotide element 1 (LINE-1) retrotransposons, constituting a substantial portion of the human genome, attracts much attention. The aim of the current study was to clarify the significance of LINE-1 methylation level for epigenetic field defects and the relationships among LINE-1 methylation level in gastric mucosae, clinical and pathological features, including infection by Helicobacter pylori (H. pylori), a bacterium implicated in gastric cancer. By bisulfite-PCR pyrosequencing, we quantified the LINE-1 methylation levels in noncancerous gastric mucosae and cancer tissues from 87 gastric cancer patients, in gastric mucosae from 17 autopsied individuals without gastric cancers and in 20 gastric fresh frozen samples from non-gastric cancer patients. LINE-1 methylation in the noncancerous gastric mucosae of gastric cancer patients was significantly higher than in cancer tissues (P = 0.0006), but significantly lower than in the gastric mucosae of the autopsied individuals (P = 0.026), suggesting the formation of ...Continue Reading

References

Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Aug 29, 2002·Helicobacter·Markus GerhardMichael Naumann
Apr 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gyeong Hoon KangHwoon-Yong Jung
Apr 19, 2003·Science·François GaudetRudolf Jaenisch
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Oct 18, 2005·Cancer Cell·Teresa M HolmRudolf Jaenisch
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takao MaekitaToshikazu Ushijima
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Mar 31, 2007·Journal of Biochemistry and Molecular Biology·Toshikazu Ushijima
Mar 28, 2008·International Journal of Cancer. Journal International Du Cancer·Shuji OginoCharles S Fuchs
Nov 27, 2008·Journal of the National Cancer Institute·Shuji OginoCharles S Fuchs
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Takayuki AndoToshikazu Ushijima
Jan 1, 2008·Environmental Health and Preventive Medicine·Takeshi NakajimaToshikazu Ushijima
Sep 19, 2009·Nature Reviews. Genetics·Richard Cordaux, Mark A Batzer
Jan 26, 2010·International Journal of Cancer. Journal International Du Cancer·Lifang HouAndrea Baccarelli
Apr 30, 2010·The New England Journal of Medicine·Kenneth E L McColl
May 25, 2010·Epigenomics·Melanie Ehrlich
Oct 1, 2010·Annals of Surgical Oncology·Kay Washington
Oct 21, 2010·CA: a Cancer Journal for Clinicians·Rodolphe Taby, Jean-Pierre J Issa
Mar 10, 2011·Nature Medicine·Manuel Rodríguez-Paredes, Manel Esteller
May 28, 2011·Journal of Clinical Pathology·Debora CompareGerardo Nardone
Jul 12, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Fang Fang ZhangAlfredo Morabia
Nov 23, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Bo-Gun Jang, Woo Ho Kim
Nov 29, 2011·International Journal of Cancer. Journal International Du Cancer·Jeong Mo BaeGyeong Hoon Kang
Dec 22, 2011·Annals of Surgical Oncology·Shiro IwagamiHideo Baba
Dec 30, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toshikazu Ushijima, Naoko Hattori
Mar 27, 2012·International Journal of Cancer. Journal International Du Cancer·Yasuhito YuasaKeitaro Matsuo
Sep 11, 2012·Cancer Prevention Research·Hiroyuki TakamaruYasuhisa Shinomura
Nov 28, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hironobu ShigakiHideo Baba
Jan 11, 2014·World Journal of Gastroenterology : WJG·Fangio Ferrari, Marco Antonio Moura Reis
Jan 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshifumi BabaHideo Baba

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Citations

Mar 15, 2016·Cancer Letters·Yoshifumi BabaHideo Baba
Aug 18, 2016·Helicobacter·Steffen BackertMichael Naumann
May 13, 2017·International Journal of Oncology·Xiao-Qing ZengShi-Yao Chen
Jul 8, 2017·Scientific Reports·Juozas KupcinskasAlexander Link

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