Relationship between low-density lipoprotein subclasses and asymptomatic atherosclerosis in subjects from the Atherosclerosis Risk in Communities (ARIC) Study

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
D Michael HallmanEric Boerwinkle

Abstract

Low-density lipoprotein (LDL) particle size has been associated with coronary heart disease, but an association between LDL size and preclinical atherosclerosis is less well established. Using gradient gel electrophoresis, large (A), intermediate (I) and small (B) LDL size subclasses were determined in 198 cases with asymptomatic carotid artery atherosclerosis (determined by B-mode ultrasonography) and 318 controls from the Atherosclerosis Risk in Communities (ARIC) Study. In Caucasians, a smaller LDL size was more prevalent in men and associated with a higher body mass index, hypertension prevalence, and plasma total- and LDL-cholesterol and triglycerides, but lower HDL-cholesterol. In African-Americans, a smaller LDL size was associated with higher triglycerides and lower HDL-cholesterol and hypertension prevalence. In Caucasians, Subclass B prevalence was 29.1% among cases and 14.8% among controls. The odds ratio (95% confidence interval) for Subclass B rather than Subclass A in Caucasian cases was 2.94 (1.67-5.17); the association remained significant after controlling for age, body mass index, smoking, and either plasma triglycerides or HDL-cholesterol. In African-Americans, however, there was no significant association be...Continue Reading

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Citations

Oct 16, 2007·International Journal of Clinical Practice·M Rizzo, K Berneis
Dec 8, 2006·Expert Opinion on Biological Therapy·Irene F GaziDimitri P Mikhailidis
Apr 21, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Manfredi RizzoJelena Vekic
Nov 3, 2006·Diabetes/metabolism Research and Reviews·Manfredi Rizzo, Kaspar Berneis
Feb 24, 2006·European Journal of Internal Medicine·Manfredi Rizzo, Kaspar Berneis
Dec 24, 2005·QJM : Monthly Journal of the Association of Physicians·M Rizzo, K Berneis
Jul 25, 2020·Scientific Reports·Zahra LotfollahiAntonio Martins Figueiredo Neto

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