Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease.

Chest
Cristine E BerryRobert A Wise

Abstract

Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment. The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV₁ (% predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores. Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95% CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points; 95% CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV₁ % predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV₁ on the total SGRQ score (P = .003) and the SF-12 PCS score (P = .03). Ther...Continue Reading

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Citations

Mar 26, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Laurie A HohbergerAndrew H Limper
Nov 5, 2016·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Fujiko SomeyaNaoki Mugii
Aug 11, 2017·Annals of the American Thoracic Society·Yet H KhorAnne E Holland
Feb 23, 2020·The European Respiratory Journal·Oliver DistlerToby M Maher
Sep 16, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sarath RajuGregory D Kirk
Jan 20, 2019·International Journal of Environmental Research and Public Health·Yuhan WenWeihong Chen
Oct 10, 2020·Health and Quality of Life Outcomes·Phillen Nozibuyiso MaqhuzuLarissa Schwarzkopf
Jul 9, 2021·International Journal of General Medicine·Luping YangRongjiang Jin

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