Mar 1, 1977

Relationship between manifestation of hyporeactivity (tolerance) in interferon production and the presence of a viral interferon inductor in the cells of the tolerant animal

Voprosy virusologii
V I MarchenkoG A Delimbetova

Abstract

Experiments revealed parallelism between the duration of the main manifestations of the hyporeactivity phenomenon (tolerance) in interferon induction and the duration of detection of a masked infection with the inducer virus (Newcastle disease virus) in peritoneal exudate cells of tolerant mice. It was also shown that after contact of chick fibroblasts with a dose of interferon which completely inhibited replication of vesicular stomatitis virus infecting the cells this virus was found in the cells in the masked form. Persistence of a virus interferon inducer in the masked form appears to play a significant role in the mechanism of tolerance as well as creation in the interferon-treated cells of conditions for masking viruses infecting these cells.

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Mentioned in this Paper

Interferon Production
Newcastle disease virus
Specimen Type - Fibroblasts
Human leukocyte interferon
Interferon
Vesicular stomatitis Indiana virus
Interferons
Interferon Inducers
Newcastle Disease
Vesiculovirus

About this Paper

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