PMID: 9538174May 9, 1998Paper

Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma

Oncology Reports
T KurizakiT Tominaga

Abstract

Intratumoral proteases are known to be involved in not only tumor cell invasion but also a variety of stromal reactions including neovascularization. In this study, we have examined the expression of matrix metalloproteinases (MMPs) by gelatin gel zymography and compared its expression with angiogenesis activities including the expression of several endothelial growth regulators and intratumoral microvessel density (MVD) in human breast cancer tissues. There was a significant correlation between activated MMP-2 expression and vascular endothelial growth factor (VEGF) expression (p=0.045). In addition, the expression of activated MMP-9 expression was significantly correlated with thymidine phosphorylase (TP) expression (p=0.0044). Pro MMP-9 expression tended to correlated with the increment of MVD (p=0.063). MMP-2 and MMP-9 expressions were frequently co-upregulated with endothelial growth regulators in human breast cancer tissues, which underlines the cooperative function of MMPs in neovascularization.

Citations

Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Aug 16, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cheng-Xiong XuMyung-Haing Cho

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