Relationship between mean corpuscular volume and cognitive performance in older adults

Journal of the American Geriatrics Society
Alyssa A GamaldoAlan B Zonderman


To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time. Longitudinal. Sample from the Baltimore Longitudinal Study of Aging (BLSA). Eight hundred twenty-seven participants from the BLSA (mean age 67, range 50-96). Mean corpuscular volume and several other blood indices were measured, including hemoglobin, iron, ferritin, vitamin B12, folate, white blood cell count, albumin, and erythrocyte sedimentation rate. Cognitive performance was examined using neuropsychological measures of visual memory, verbal memory, language, attention, executive function, and global mental status. High MCV levels were significantly associated with lower global mental status even after adjusting for potential confounders. High MCV levels were also significantly associated with high rates of decline on tasks of global mental status, long delay memory, and attention, even after adjusting for potential confounders. The findings confirm a previous observation that larger erythrocytes in older adults are associated with poorer cognitive function. Anemia and inflammation do not appear to explain the relationship between MCV and cognition. Further research is needed to clarify the mechanisms behind t...Continue Reading


Jan 15, 2013·Journal of the American Geriatrics Society·Joe Verghese
Feb 4, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yu TaniguchiYoshinori Fujiwara
Oct 23, 2014·Arquivos de neuro-psiquiatria·Gustavo José LuvizuttoRodrigo Bazan
Apr 18, 2018·Clinical Hemorheology and Microcirculation·Michael J FalvoMichael R Condon


Jan 1, 1979·Gerontology·Y MatznerC Hershko
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1990·Experimental Gerontology·T Shperling, D Danon
Jul 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·G BlessedM Roth
Jan 1, 1982·Journal of Gerontology·D Arenberg
Jul 5, 1996·Science·R S Sohal, R Weindruch
Aug 17, 1999·Annual Review of Nutrition·H W Baik, R M Russell
Mar 31, 2004·The American Journal of Medicine·Claudia BeghéWilliam B Ershler
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Dec 2, 2004·Blood·Luigi FerrucciDan L Longo
May 4, 2005·Journal of the Society for Gynecologic Investigation·Samuel LurieMarek Glezerman
May 23, 2007·Aging Cell·Wulf Dröge, Hyman M Schipper
Dec 6, 2011·Journal of the American Geriatrics Society·Alyssa A GamaldoAlan B Zonderman

Related Concepts

Erythrocyte Sedimentation Rate Measurement
Memory for Designs Test
Vitamin B 12
White Blood Cell Count Procedure
Vitamin B12 [EPC]
Mean Corpuscular Hemoglobin Concentration Determination
Hemoglobin Measurement

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.


Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.