PMID: 12773461May 30, 2003Paper

Relationship between meiotic spindle location with regard to the polar body position and oocyte developmental potential after ICSI

Human Reproduction
L RienziE Greco

Abstract

The recent development of a computer-assisted polarization microscopy system (Polscope) with which the meiotic spindle can be visualized in living oocytes on the basis of its birefringence permits analysis of the meiotic spindles of oocytes subjected to ICSI. Previous studies have shown that the meiotic spindle is not always aligned with the first polar body (PB) in metaphase II human oocytes prepared for ICSI. In the present study, the relationship between the degree of meiotic spindle deviation from the first PB location and ICSI outcome was analysed. Oocytes were divided into four groups according to the angle of meiotic spindle deviation from the PB position. The angle of deviation was 0-5 degrees, 6-45 degrees, 46-90 degrees and >90 degrees for groups I to IV respectively. The rates of normal [2 pronuclei (PN)] and abnormal (1PN or >2PN) fertilization did not differ between groups I, II and III. However, the rate of normal fertilization was lower among oocytes in which the meiotic spindle deviation angle was >90 degrees; this led to an increased proportion of tripronucleated zygotes that failed to extrude the second PB. When embryos developed from normally fertilized oocytes were evaluated on day 3 after ICSI, no relations...Continue Reading

Citations

Mar 23, 2006·Journal of Assisted Reproduction and Genetics·Atsushi YanaiharaTakashi Okai
Sep 28, 2007·Journal of Assisted Reproduction and Genetics·Cong FangMilton Leong
Dec 12, 2012·Journal of Assisted Reproduction and Genetics·Karolina Piotrowska-Nitsche, Anthony W S Chan
Jun 14, 2008·Reproductive Biomedicine Online·H Nadir CirayMustafa Bahçeci
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