Relationship between melatonin and bone resorption rhythms in premenopausal women

Journal of Bone and Mineral Metabolism
Melissa A St HilaireS W Lockley

Abstract

Although evidence exists for a daily rhythm in bone metabolism, the contribution of factors such as melatonin levels, the light-dark cycle, and the sleep-wake cycle is difficult to differentiate given their highly correlated time courses. To examine these influences on bone resorption, we collected 48-h sequential urine samples under both ambulatory (8-h sleep:16-h wake) and constant routine (CR) (constant wake, posture, nutrition and dim light) conditions from 20 healthy premenopausal women. Urinary 6-sulphatoxymelatonin (aMT6s; ng/h) and the bone resorption marker amino-terminal cross-linked collagen I telopeptide (NTx; bone collagen equivalents nM/h) were assayed and fit by cosinor models to determine significant 24-h rhythms and acrophase. Most participants had significant 24-h aMT6s rhythms during both ambulatory and CR conditions (95 and 85%, respectively), but fewer had significant 24-h NTx rhythms (70 and 70%, respectively). Among individuals with significant rhythms, mean (± SD) aMT6s acrophase times were 3:57 ± 1:50 and 3:43 ± 1:25 h under ambulatory and CR conditions, respectively, and 23:44 ± 5:55 and 3:06 ± 5:15 h, respectively, for NTx. Mean 24-h levels of both aMT6s and NTx were significantly higher during CR com...Continue Reading

References

Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C HassagerC Christiansen
Mar 1, 1992·The Journal of Clinical Endocrinology and Metabolism·A SchlemmerC Christiansen
Mar 1, 1992·The Journal of Clinical Endocrinology and Metabolism·R EastellB L Riggs
Feb 1, 1991·The Journal of Clinical Endocrinology and Metabolism·D UebelhartP D Delmas
May 1, 1988·Annals of Clinical Biochemistry·M E Aldhous, J Arendt
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·G el-Hajj FuleihanC A Czeisler
May 1, 1997·Calcified Tissue International·S L GreenspanL Ferguson
Nov 14, 1997·The Journal of Clinical Endocrinology and Metabolism·S W LockleyR Defrance
Jan 31, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·C de la PiedraM Sosa Henríquez
May 26, 1998·Bone·A LeBlancV Schneider
Jul 27, 1999·The Journal of Biological Chemistry·J A RothM I Cho
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D J DijkC A Czeisler
Jan 29, 2002·Life Sciences·M G LadizeskyD P Cardinali
Feb 12, 2002·Journal of Biological Rhythms·Jeanne F Duffy, Derk-Jan Dijk
Jul 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroki KoyamaK H William Lau
Oct 23, 2002·Journal of Pineal Research·Nobuo Suzuki, Atsuhiko Hattori
Feb 4, 2003·Journal of Pineal Research·Daniel P CardinaliCarlos Mautalen
Apr 19, 2005·Journal of Biological Rhythms·Kenneth P WrightCharles A Czeisler
Jun 7, 2007·The Journal of Clinical Endocrinology and Metabolism·F JosephW D Fraser
Sep 4, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D FeskanichE S Schernhammer
May 14, 2010·Science Translational Medicine·Joshua J GooleySteven W Lockley
Jun 4, 2010·American Journal of Physiology. Renal Physiology·Konstantinos KamperisJens Christian Djurhuus
Oct 30, 2010·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Ivan Quevedo, Ana M Zuniga
Dec 29, 2010·Frontiers in Neurology·Tracey L SlettenShantha M W Rajaratnam
Jan 5, 2011·The Journal of Clinical Endocrinology and Metabolism·Joshua J GooleySteven W Lockley
Mar 25, 2011·Clinical Oral Investigations·Gretel G PellegriniSusana N Zeni
Sep 22, 2012·Journal of Applied Physiology·Jennifer L L MorganScott M Smith
Nov 13, 2012·Journal of Bone and Mineral Metabolism·Yoshiki NishizawaNoriko Yoshimura
Aug 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Eric Chern-Pin ChuaJoshua J Gooley
Jun 12, 2014·Journal of Biological Rhythms·Erin E Flynn-EvansSteven W Lockley
Oct 27, 2015·Endocrine Regulations·R CappellessoD Pizzol
Nov 17, 2015·Sleep Medicine Clinics·Jeanne F DuffyEvan D Chinoy

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Citations

Jan 1, 2019·Journal of Pineal Research·Tian LiYang Yang
Jul 10, 2019·Journal of Pineal Research·Mika IkegameNobuo Suzuki
May 27, 2020·Current Opinion in Nephrology and Hypertension·Søren EgstrandEwa Lewin
May 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Christine M SwansonOrfeu M Buxton
Nov 30, 2018·Frontiers in Physiology·Felice StrolloJoan Vernikos
Jan 5, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kyota IshibashiYasuyuki Ishibashi
May 10, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Christine M Swanson
Jul 4, 2021·Bone·Christopher M DepnerChristine M Swanson

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