PMID: 6163627Jan 1, 1981Paper

Relationship between methylation of adenine near the 3' end of 16-S ribosomal RNA and the activity of 30-S ribosomal subunits

European Journal of Biochemistry
K IgarashiS Hirose

Abstract

The relationship between methylation of adenine near the 3' end of 16-S ribosomal RNA and the activity of 30-S ribosomal subunits has been studied using 30-S subunits from kasugamycin-sensitive and kasugamycin-resistant bacteria. Analysis of the proteins of 30-S subunits by gel electrophoresis showed that the content of protein S1 in 30-S subunits from a kasugamycin-resistant strain was smaller than that in 30-S subunits from the parent strain. Although polyphenylalanine-synthetic activity of 30-S subunits from a kasugamycin-resistant strain previously methylated by a methylase purified from Escherichia Q13 was nearly equal to that of untreated 30-S subunits, both phenylalanine-synthetic activity and the content of protein S1 in the 30-S particles reconstituted from 23-S core particles and split proteins from the kasugamycin-resistant strain increased by prior methylation of 23-S core particles by the methylase. These results suggest that methylation of adenine near the 3' end of 16-S rRNA induces an increase of polypeptide-synthetic activity by the acceleration of binding of protein S1 to S1-depleted 30-S subunits.

References

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Citations

May 12, 2004·Journal of Molecular Biology·Heather C O'FarrellJason P Rife
Jul 15, 1986·European Journal of Biochemistry·T KakegawaK Igarashi
Jul 5, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuei Igarashi
Dec 23, 2008·International Journal of Antimicrobial Agents·Paul M Duffin, H Steven Seifert
Nov 8, 2008·Molecular Microbiology·Keith ConnollyGloria Culver
Jan 24, 2006·Journal of Biochemistry·Kazuei Igarashi, Keiko Kashiwagi
Feb 16, 2006·The Journal of Biological Chemistry·Kyohei HigashiKazuei Igarashi
Aug 16, 2018·The Journal of Biological Chemistry·Kazuei Igarashi, Keiko Kashiwagi
Sep 21, 2004·The Biochemical Journal·Kazuhiro NishimuraKazuei Igarashi
May 18, 2000·Biochemical and Biophysical Research Communications·T CaldasG Richarme
Dec 14, 1993·Biochimica Et Biophysica Acta·H G NastriI D Algranati
Feb 22, 1983·Biochimica Et Biophysica Acta·K IgarashiS Hirose
Jan 1, 1989·Archives of Biochemistry and Biophysics·K KashiwagiK Igarashi
Mar 1, 1988·Archives of Biochemistry and Biophysics·T KakegawaK Igarashi
Dec 1, 1986·Archives of Biochemistry and Biophysics·T KakegawaK Igarashi
Apr 20, 2006·Archives of Biochemistry and Biophysics·Pooja M Desai, Jason P Rife

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