Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans

American Journal of Physiology. Heart and Circulatory Physiology
Nisha CharkoudianB G Wallin

Abstract

Large interindividual differences exist in resting sympathetic nerve activity (SNA) among normotensive humans with similar arterial pressure (AP). We recently showed inverse relationships of resting SNA with cardiac output (CO) and vascular adrenergic responsiveness that appear to balance the influence of differences in SNA on blood pressure. In the present study, we tested whether nitric oxide (NO)-mediated vasodilation has a role in this balance by evaluating hemodynamic responses to systemic NO synthase (NOS) inhibition in individuals with low and high resting muscle SNA (MSNA). We measured MSNA via peroneal microneurography, CO via acetylene uptake and AP directly, at baseline and during increasing systemic doses of the NOS inhibitor NG-monomethyl-L-arginine (L-NMMA). Baseline MSNA ranged from 9 to 38 bursts/min (13 to 68 bursts/100 heartbeats). L-NMMA caused dose-dependent increases in AP and total peripheral resistance and reflex decreases in CO and MSNA. Increases in AP with L-NMMA were greater in individuals with high baseline MSNA (PANOVA<0.05). For example, after 8.5 mg/kg of L-NMMA, in the low MSNA subgroup (n=6, 28+/-4 bursts/100 heartbeats), AP increased 9+/-1 mmHg, whereas in the high-MSNA subgroup (n=6, 58+/-3 bu...Continue Reading

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Citations

May 11, 2011·Journal of Natural Medicines·Parirat KhonsungS Intahphuak
Feb 5, 2011·Current Hypertension Reports·Emma C Hart, Nisha Charkoudian
Jul 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mark A BlackDaniel J Green
Jan 31, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Alfredo GamboaItalo Biaggioni
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N CharkoudianJ Osborn
Dec 24, 2011·Journal of Applied Physiology·John H EisenachWayne T Nicholson
Mar 30, 2013·Biology of Sex Differences·Virginia M MillerWalter A Rocca
Sep 5, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Michael J Joyner, Darren P Casey
Oct 1, 2013·European Journal of Applied Physiology·J Andrew Taylor, Can Ozan Tan
Sep 24, 2008·Expert Opinion on Investigational Drugs·Laurence Guy Howes, Divina Gracila Brillante
Dec 2, 2009·The Journal of Physiology·Darren P CaseyMichael J Joyner
May 5, 2011·The Journal of Physiology·Emma C HartNisha Charkoudian
Sep 9, 2009·The Journal of Physiology·Michael J Joyner, Daniel J Green
Apr 29, 2014·American Journal of Obstetrics and Gynecology·Ralph R ScholtenMarc E A Spaanderman
Mar 19, 2009·European Journal of Clinical Investigation·D G BrillanteL G Howes
Sep 23, 2014·Autonomic Neuroscience : Basic & Clinical·Bruno M SilvaAntonio C L Nobrega
Nov 29, 2014·Rejuvenation Research·Nuria GaratacheaAlejandro Lucia
Apr 2, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Emma C HartJohn W Osborn
Nov 30, 2006·Hypertension·Alfredo GamboaItalo Biaggioni
Mar 11, 2008·Experimental Physiology·Michael J JoynerB Gunnar Wallin
Oct 3, 2012·The Journal of Physiology·Megan M Wenner, Nina S Stachenfeld
Sep 3, 2013·Physiology·Carmen Fiuza-LucesAlejandro Lucia
Jul 31, 2008·Stem Cell Reviews·Peter J Quesenberry, Jason M Aliotta
Jan 15, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Emma C HartNisha Charkoudian
May 17, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Elisabeth A LambertGavin W Lambert
Nov 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sylvain BattaultCyril Reboul
Oct 30, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jill M WechtWilliam A Bauman

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