Relationship between negative symptoms in chronic schizophrenia and neuroleptic dose, plasma levels and side effects

Schizophrenia Research
L A TuggR B Zipursky

Abstract

The negative symptoms of schizophrenia are often difficult to distinguish from the side effects of antipsychotic medication. In this study, we tried to clarify this issue by studying a group of patients in a clinic setting where a wide range of antipsychotic doses were being prescribed. Thirty-one patients meeting DSM-III-R criteria for schizophrenia or schizoaffective disorder were studied. Clinical ratings were carried out to assess the positive and negative symptoms of schizophrenia, parkinsonism, akathisia and tardive dyskinesia. Plasma levels were also measured for the majority of patients. Antipsychotic plasma levels were found to be highly correlated with dose. Antipsychotic dose and plasma levels were not correlated with the severity of negative symptoms, akathisia or parkinsonism. However, the severity of positive symptoms and tardive dyskinesia were positively correlated with both dose and plasma level. These findings do not support the hypothesis that higher doses of antipsychotic medication are associated with more severe negative symptoms.

References

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Citations

Oct 19, 2000·The Australian and New Zealand Journal of Psychiatry·P MorrisonP Collings
Sep 17, 2014·Schizophrenia Research·Jiang Li, Herbert Y Meltzer
Jan 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gagan FervahaGary Remington
May 28, 2016·Schizophrenia Research·Matthias KirschnerStefan Kaiser
Jan 1, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·S S PotaninI I Miroshnichenko

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