Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Jean R GesteAdriaan W Bruijnzeel

Abstract

Tobacco use improves mood states and smoking cessation leads to anhedonia, which contributes to relapse. Animal studies have shown that noncontingent nicotine administration enhances brain reward function and leads to dependence. However, little is known about the effects of nicotine self-administration on the state of the reward system. To investigate the relationship between nicotine self-administration and reward function, rats were prepared with intracranial self-stimulation electrodes and intravenous catheters. The rats were trained on the intracranial self-stimulation procedure and allowed to self-administer 0.03 mg/kg/infusion of nicotine. All rats self-administered nicotine daily for 10 days (1 hour/day) and were then switched to an intermittent short access (ShA, 1 hour/day) or long access (LgA, 23 hour/day) schedule (2 days/week, 5 weeks). During the first 10 daily, 1-hour sessions, nicotine self-administration decreased the reward thresholds, which indicates that nicotine potentiates reward function. After switching to the intermittent LgA or ShA schedule, nicotine intake was lower in the ShA rats than the LgA rats. The LgA rats increased their nicotine intake over time and they gradually consumed a higher percentage...Continue Reading

References

Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·D H MalinO B Wilson
Jan 1, 1989·Psychopharmacology·W A Corrigall, K M Coen
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J M Liebman
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·P J FudalaE T Iwamoto
Jan 1, 1986·Psychopharmacology·R Nemeth-CoslettR R Griffiths
Jan 1, 1973·Psychopharmacologia·I P StolermanM E Jarvik
May 1, 1996·Neuron·J A Dani, S Heinemann
May 20, 1998·Nature·M P Epping-JordanA Markou
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·S S WatkinsA Markou
May 18, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A MarkouB J Everitt
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S H AhmedG F Koob
Sep 27, 2001·The Journal of Endocrinology·C Fernández-GalazJ M Carrascosa
Oct 9, 2002·Trends in Pharmacological Sciences·Alasdair M BarrAnthony G Phillips
Nov 11, 2003·Trends in Pharmacological Sciences·Edwin H JacobsAnton N M Schoffelmeer
Sep 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J Kenny, Athina Markou
Mar 23, 2006·Psychopharmacology·Osamu KitamuraLuigi Pulvirenti
Oct 20, 2006·The Journal of Pharmacology and Experimental Therapeutics·Laura E O'DellGeorge F Koob
Jan 30, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Saadhna PandayHein de Vries
Jan 12, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Deborah M ScharfSaul Shiffman
Feb 13, 2008·Experimental and Clinical Psychopharmacology·Andrew C HarrisMark G LeSage
Jan 6, 2009·Pharmacology, Biochemistry, and Behavior·Laura E O'Dell, Taline V Khroyan
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Catherine A MarcinkiewczAdrie W Bruijnzeel
Sep 30, 2010·Journal of Biological Rhythms·Michael E HughesKarl Kornacker
Dec 20, 2011·Trends in Neurosciences·Andre Der-Avakian, Athina Markou
Mar 13, 2012·Neuroscience and Biobehavioral Reviews·Adrie W Bruijnzeel
May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami CohenOlivier George
Aug 24, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Moe IgariAdrie W Bruijnzeel
Nov 14, 2013·Journal of Consulting and Clinical Psychology·Adam M LeventhalJessica W Cook
Jun 24, 2015·Chronobiology International·Hannah R TranelJody L Clasey
Jul 28, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xiaoli QiAdriaan W Bruijnzeel
Dec 29, 2016·Psychopharmacology·Adriaan W Bruijnzeel

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Citations

Jan 8, 2021·Psychopharmacology·Ranjithkumar ChellianAdriaan W Bruijnzeel
May 15, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ranjithkumar ChellianAdriaan W Bruijnzeel

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