PMID: 16646288May 2, 2006Paper

Relationship between nitrogen oxide and the degree of metabolic control of diabetes mellitus type 1 in children and adolescents

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Zdzisława IwanickaBozena Kotschy

Abstract

Diabetes mellitus is a disease with early endothelium injury. The most important damaging reactions of endothelium may be the abnormal synthesis of nitrogen oxide. The aim of the study was the evaluation of nitrogen oxide serum concentration in young patients with diabetes mellitus type 1 depending on glycated haemoglobin (HbA1c) concentration and parameters of lipoproteins metabolism. Ninety one children and adolescents (36/55, M/F) in the age 13.0 +/- 3.5 y., with mean diabetes duration 3.2 +/- 3.8 were examined. The control group consisted of 23 healthy volunteers. The degree of glycaemic control was taken into account (subgroup I - good glycaemic control HbA1c < 6.5%; II--sufficient HbA1c < or = 8.0% and III--poor glycaemic control HbA1c > 8.0%). Venous blood was used as a diagnostic material. In all cases fasting nitrogen oxide concentration measured indirectly by the level of nitrites (NO2-) and nitrates (NO3-) (micromol/L); triglycerides, total cholesterol, LDL and HDL cholesterol (mmol/L) were assessed. The mean NO2- (59.20 +/- 56.77) and NO3- (53.90 +/- 56.63) concentrations were the highest in subgroup III (HbA1c- 9.72 +/- 1.21; T-Ch 5.40 +/- 1.04; TGL 2.11 +/- 1.54; LDL-Ch 3.07 +/- 0.91; HDL-Ch 0.97 +/- 0.19) and dif...Continue Reading

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