Relationship between non-alcoholic fatty liver disease and coronary heart disease

World Journal of Clinical Cases
Ugur Arslan, Mustafa Yenerçağ

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease and considered a liver manifestation of metabolic syndrome. It is in close relationship with insulin resistance, obesity, diabetes mellitus, all of which increase risk of cardiovascular disease (CVD). Besides, many studies point out that NAFLD independently contributes to the development of atherosclerosis and CHD. On the other hand, CVDs are the leading cause of death in NAFLD patients. Many pathophysiological changes and molecular mechanisms play an important role in NAFLD for CVD formation. Atherosclerosis is common in NAFLD, which also mainly contributes to the CVD formation and CHD. Many studies linking atherosclerotic CHD and NAFLD are present in the literature. Subclinical CHD, mainly detected by coronary computed tomography views, have been detected more common in NAFLD patients. Presence of NAFLD has been found to be more common in patients with severe CHD and in stable CHD, NAFLD has been found to be associated with more diffuse disease. In acute coronary syndromes, especially in acute myocardial infarction, patients with NAFLD have been found to have poor prognosis when compared with NAFLD free patients. In this review, our aim is...Continue Reading

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Citations

Mar 20, 2021·Antioxidants & Redox Signaling·Andrea Morán-CostoyaAdamo Valle
May 1, 2021·Journal of Clinical Medicine·Mohammad Said RamadanRosa Zampino
Sep 25, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jonathan Zhi Kai TohMohammad Shadab Siddiqui

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Methods Mentioned

BETA
biopsy

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