Relationship between noninvasive scores of nonalcoholic fatty liver disease and nuclear magnetic resonance lipoprotein abnormalities: A focus on atherogenic dyslipidemia

Journal of Clinical Lipidology
Antonio J AmorEmilio Ortega

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an emerging, highly prevalent, cardiovascular risk factor, and lipoprotein proatherogenic disturbances likely explain a large part of this risk. However, information regarding associations between detailed nuclear magnetic resonance (NMR) lipoprotein changes and noninvasive NAFLD scores is lacking. The objective of the study was to investigate the NMR-assessed atherogenic lipoprotein profile according to noninvasive NAFLD status. Lipoprotein profiles by NMR spectroscopy and NAFLD status by fatty liver index (FLI) and Gholam's models. We assessed 173 participants (55% males), mean age 60.8 ± 7.8 years, 87% overweight/obese, 53% with diabetes. An FLI <30, 30 to 60, and >60 was found in 32, 50, and 91 participants, respectively. Individuals with FLI >60 had lower high-density lipoprotein (HDL)-cholesterol (P < .001), higher triglyceride (P < .001), and similar non-HDL-cholesterol (P = .912) concentrations. In NMR analysis, FLI was related with very-low-density lipoprotein (VLDL) and HDL parameters in a dose-dependent manner. VLDL particle number (P < .001) and VLDL size (39.1 ± 0.99, 39.7 ± 0.96, 40.8 ± 1.19 nm, P < .001) increased with increased FLI (<30, 30-60, and >60, respectively). ...Continue Reading

Citations

Jan 30, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Antonio J Amor, Verónica Perea
Jun 10, 2020·Diabetes/metabolism Research and Reviews·Antonio J AmorVerónica Perea
Aug 11, 2020·Cardiovascular Diabetology·Antonio J AmorDidac Mauricio
May 16, 2019·Annals of Clinical Biochemistry·Jelena JanacVesna Spasojević-Kalimanovska
Apr 24, 2021·Molecular Metabolism·Joerg Heeren, Ludger Scheja

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