Abstract
Analyze the relationship between obesity and type-2 diabetes mellitus (DM) and the development of differentiated thyroid cancer (DTC). A randomized case-controlled retrospective chart review of outpatient clinic patients at an academic medical center between January 2005 and December 2012. DTC patients were compared to two control groups: primary hyperparathyroidism (PHPTH) patients with euthyroid state and Internal Medicine (IM) patients. Exposure variables included historical body-mass-index (BMI), most recent BMI within 6 months and DM. Multivariate logistic regressions adjusting for gender, age, and year of BMI assessed the adjusted Odds Ratio (OR) of DTC with both BMI and DM. Comparison of means showed a statistically significant higher BMI in DTC (BMI=37.83) than PHPTH, IM, and pooled controls, BMI=30.36 p=<0.0001, BMI=28.96 p=<0.0001, BMI=29.53 p=<0.0001, respectively. When compared to PHPTH, DM was more frequent in DTC (29% vs. 16%) and prevalence trended towards significance (p=0.0829, 95% CI =0.902-5.407). BMI adjusted OR was significant when compared to PHPTH, IM and pooled controls: 1.125 (p=0.0001), 1.154 (p=<0.0001), and 1.113 (p=<0.0001), respectively. DM adjusted OR was significant when compared to PHPTH and poo...Continue Reading
References
Mar 1, 1991·The British Journal of Nutrition·P DeurenbergJ C Seidell
Mar 7, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter SzlosarekFrances R Balkwill
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·Alessandro FedericoCarmela Loguercio
Dec 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Megan Rist HaymartHerbert Chen
Jul 22, 2009·Endocrine-related Cancer·Paolo VigneriRiccardo Vigneri
Nov 7, 2009·Asian Journal of Surgery·Melih AkinciAbdullah Cetin
Jun 22, 2010·American Journal of Surgery·Luc G T Morris, David Myssiorek
Jan 27, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cari M KitaharaAmy Berrington de González
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Cari M KitaharaAmy Berrington de González
Jul 20, 2011·Thyroid : Official Journal of the American Thyroid Association·Briseis Aschebrook-KilfoyMary H Ward
Sep 3, 2011·Diabetes, Obesity & Metabolism·E Fröhlich, R Wahl
Dec 30, 2011·Medicina clínica·Hector-Eloy Tamez-PérezEnrique Díaz de León-González
Jul 11, 2012·Experimental Diabetes Research·Shyang-Rong ShihChin-Hsiao Tseng
Jul 21, 2012·Clinical Endocrinology·Hye Jeong KimSun Wook Kim
Nov 21, 2012·Nutrition and Cancer·Marjory Alana MarcelloLaura Sterian Ward
Feb 5, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·B D Schoub
Feb 22, 2014·Thyroid : Official Journal of the American Thyroid Association·Li XuErich M Sturgis
Feb 22, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, H Gilbert Welch
Aug 30, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Darrin V BannDavid Goldenberg
Citations
Mar 26, 2016·The Journal of Nutritional Biochemistry·Jing Xue, Folami Y Ideraabdullah
Jan 17, 2017·Comptes rendus biologies·Rajan Kumar SinghKulandaivelu Mahalingam
Mar 23, 2017·Medicine·Yuerong YanHui Huang
Dec 1, 2017·Frontiers in Endocrinology·Roberta MalaguarneraAntonino Belfiore
May 29, 2018·Thyroid : Official Journal of the American Thyroid Association·Yoon Young ChoSun Wook Kim
Sep 16, 2018·Endocrine·Eunice NyasaniSalma Khan
Apr 24, 2019·Cancer·David Goldenberg
Oct 27, 2018·Pathology Oncology Research : POR·Xiaolin YangWeijuan Li
Jun 26, 2020·BioFactors·Wei Cui, Jun Xue
Nov 1, 2017·International Journal of Endocrinology·Shi-Tong YuXiaoming Huang
Sep 19, 2020·BMC Cancer·Elena IzkhakovJoseph Meyerovitch
Sep 12, 2018·World Journal of Surgical Oncology·Lihong Cao
Dec 20, 2019·Medicine·Sitong ZhaoZhaohui Lyu
Feb 6, 2021·Hormone Molecular Biology and Clinical Investigation·Mohammad JamshidiMohammad-Reza Mahmoudian-Sani
Nov 27, 2020·PeerJ·Jiaming ChenJugao Fang
Aug 12, 2019·Annales d'endocrinologie·Mohamad ZalzaliClaire Schvartz
May 5, 2021·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Jane R SchubartDavid Goldenberg
Apr 29, 2021·Archives of Endocrinology and Metabolism·Onur Elbasan, Dilek Gogas Yavuz
Jun 8, 2021·Cancer Epidemiology·Jia-Liu HeFen Huang
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Laya SoleimanisardooMohammad Hossein Gozashti
Jun 26, 2018·Surgical Oncology·Haiyoung SonIlkyun Lee
Aug 1, 2021·The Journal of Infectious Diseases·Nusrat J EpsiUNKNOWN EPICC COVID-19 Cohort Study Group