Relationship Between Optic Nerve Protrusion Measured by OCT and MRI and Papilledema Severity

Investigative Ophthalmology & Visual Science
Yu-Cherng C ChangByron L Lam

Abstract

To develop measures of optic nerve protrusion length (NPL) from optical coherence tomography (OCT) and magnetic resonance imagining (MRI) and compare these measures with papilledema severity in idiopathic intracranial hypertension (IIH). Optical coherence tomography and MRI scans were obtained from 11 newly diagnosed untreated IIH patients (30 ± 10 years; body mass index [BMI] 36 ± 4 kg/m2). Optic nerve protrusion length was measured for each eye using OCT and MRI independently. The relationship between the NPL measures and their association with the Frisen scale for papilledema severity were assessed. Two different OCT-based measures of NPL were derived to assess the influence of the retinal thickness on the association with papilledema severity. Additional OCT scans from 11 healthy subjects (38 ± 7 years) were analyzed to establish reliability of the NPL measurement. Optical coherence tomography and MRI measurements of NPL were significantly linearly correlated (R = 0.79, P < 0.0001). Measurements of NPL from OCT and MRI were significantly associated with Frisen papilledema grade (P < 0.0001). Mean OCT measurement of NPL in the papilledema cohort was significantly larger than in the healthy cohort (0.62 ± 0.24 vs. 0.09 ± 0.03...Continue Reading

Citations

Dec 27, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y Huang-LinkY-P Jin
Nov 25, 2020·Current Opinion in Neurology·Arhem F BarkatullahHeather E Moss
Feb 23, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mika Shapira RootmanOsnat Konen
Jul 29, 2021·Journal of Brachial Plexus and Peripheral Nerve Injury·Alec GironBrendan MacKay

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