Relationship between pain and motor and non-motor symptoms in Parkinson's disease

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G DefazioA Berardelli

Abstract

Although female gender, depressive symptoms and medical conditions predisposing to pain are more common in patients with Parkinson's disease (PD) with pain, no study has yet explored the relationship between pain and other non-motor symptoms (NMS). A total of 321 consecutive patients with PD [190 men/131 women aged 68.3 (SD 9.2) years] attending four Italian movement disorder clinics were studied. Demographic/clinical data were obtained by a standardized interview and the NMS scale. The association of pain with motor and NMS was assessed by multivariable logistic regression models. At the time of the study, 180 patients with PD (56%) reported chronic pain that, in most cases, was described as being muscular or arthralgic pain. Pain preceded the onset of motor signs in 36/180 patients. In the main-effect model, factors independently associated with pain were female sex [odds ratio (OR), 2.1; P = 0.01], medical conditions predisposing to pain (OR, 2.9; P < 0.001), Hoehn-Yahr staging (OR, 1.9; P = 0.04), motor complications (OR, 4.7; P = 0.04) and NMS belonging to the sleep/fatigue (OR, 1.6; P = 0.04) and mood/cognition (OR, 1.6; P = 0.03) domains. Most explanatory variables in the multivariable analysis were similarly distributed...Continue Reading

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Citations

Jun 8, 2019·Pain Practice : the Official Journal of World Institute of Pain·Danielle C de MattosLaura Alice Santos de Oliveira
Mar 10, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A AntoniniO Rascol
Sep 18, 2018·Neurological Research·Abdul Qayyum RanaRuqqiyah Rana
Dec 12, 2018·Frontiers in Aging Neuroscience·Gwenda EngelsLinda Douw
Oct 23, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Nov 19, 2020·Scientific Reports·Giulia PaparellaMatteo Bologna
May 27, 2021·Brain : a Journal of Neurology·Abteen MostofiErlick A C Pereira
Jul 6, 2021·Parkinson's Disease·N Vila-ChãJ M Castro-Lopes
Nov 28, 2019·Clinical Parkinsonism & Related Disorders·Yi-Cheng Tai, Chin-Hsien Lin

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