Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature

Mediators of Inflammation
Vilana Maria Adriano AraújoVilma Lima

Abstract

Periodontitis (PD) and rheumatoid arthritis (RA) are immunoinflammatory diseases where leukocyte infiltration and inflammatory mediators induce alveolar bone loss, synovitis, and joint destruction, respectively. Thus, we reviewed the relationship between both diseases considering epidemiological aspects, mechanical periodontal treatment, inflammatory mediators, oral microbiota, and antibodies, using the keywords "periodontitis" and "rheumatoid arthritis" in PubMed database between January 2012 and March 2015, resulting in 162 articles. After critical reading based on titles and abstracts and following the inclusion and exclusion criteria, 26 articles were included. In the articles, women over 40 years old, smokers and nonsmokers, mainly constituted the analyzed groups. Eight studies broached the epidemiological relationship with PD and RA. Four trials demonstrated that the periodontal treatment influenced the severity of RA and periodontal clinical parameters. Nine studies were related with bacteria influence in the pathogenesis of RA and the presence of citrullinated proteins, autoantibodies, or rheumatoid factor in patients with PD and RA. Five studies investigated the presence of mediators of inflammation in PD and RA. In su...Continue Reading

References

Apr 16, 2002·Arthritis and Rheumatism·Elena NeumannUlf Müller-Ladner
Feb 11, 2005·British Dental Journal·G M J DeemingM N Pemberton
Apr 26, 2005·British Dental Journal·M RazaliR F Wilson
Sep 1, 2005·Journal of Clinical Periodontology·Bruno G LoosMarja L Laine
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Peter S BurrageConstance E Brinckerhoff
Jun 7, 2007·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mhd Khaldoun Al-KatmaAli D Askari
Jun 16, 2007·Lancet·Josef S SmolenPaul Emery
May 7, 2010·Inflammation·Georgios N BelibasakisNagihan Bostanci
Mar 1, 2011·Journal of Clinical Periodontology·Denis F KinaneUNKNOWN Working Group 2 of Seventh European Workshop on Periodontology
Feb 26, 2011·Journal of Clinical Periodontology·Gabriel Nussbaum, Lior Shapira
Mar 26, 2011·Journal of Clinical Periodontology·Melissa D CantleyP Mark Bartold
Apr 8, 2011·Journal of Dental Research·M HernándezJ Gamonal
Jul 19, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Balkees Taha Garib, Sarhang S Qaradaxi
Jul 29, 2011·Trends in Pharmacological Sciences·Maria Carmen MartinezRamaroson Andriantsitohaina
Oct 6, 2011·Annals of the Rheumatic Diseases·Mitra PikwerCarl Turesson
Nov 8, 2011·Rheumatology International·Shengqian XuJianhua Xu
Nov 30, 2011·Journal of Periodontology·Kohei IshidaHiromasa Yoshie
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Mar 20, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Stéphanie TémoinNabil F Bissada
May 12, 2012·Arthritis and Rheumatism·Jose U ScherSteven B Abramson
May 26, 2012·Journal of Indian Society of Periodontology·Sarika Bhalgat Ranade, Satish Doiphode
Jul 18, 2012·Journal of Periodontal & Implant Science·Parviz TorkzabanJalal Poorolajal
Oct 30, 2012·Annals of the Rheumatic Diseases·Maria J H de HairPaul P Tak
Dec 4, 2012·Journal of Clinical and Diagnostic Research : JCDR·D Manivelavan, Vijayasamundeeswari C K

❮ Previous
Next ❯

Citations

Mar 1, 2016·Journal of Periodontology·Nicole PischonGabriela Riemekasten
Feb 7, 2017·Journal of Dental Research·D KimJ Ryu
Sep 13, 2017·International Reviews of Immunology·Scott Le RossignolNagaraja Haleagrahara
Jul 4, 2018·Oral Diseases·Leena ÄyräväinenTimo Sorsa
Jun 20, 2018·Clinical and Experimental Immunology·F De Luca, Y Shoenfeld
Nov 20, 2016·British Dental Journal·S de SouzaJ Galloway
May 8, 2019·International Journal of Rheumatic Diseases·Małgorzata Radwan-OczkoClaus Rasmussen
Apr 3, 2020·Acta Odontologica Scandinavica·Van Bich NguyenHung Tu Hoang
May 18, 2020·The Journal of Pathology·Hua WangWen Sun
Feb 13, 2017·Clinical Oral Investigations·Sophia MühlbergDirk Ziebolz
Sep 19, 2019·Rheumatology International·Susana Aideé González-ChávezRosa María Campos-Torres
Sep 22, 2019·International Journal of Molecular Sciences·Rafael Scaf de MolonMarije I Koenders
Dec 18, 2019·Pediatric Rheumatology Online Journal·Sriharsha GrevichAnne Stevens
Jul 25, 2019·Frontiers in Immunology·Ulrike SteffenAline Bozec
Aug 29, 2019·Journal of Clinical Medicine·Eduardo Gómez-BañuelosFelipe Andrade
Jun 14, 2020·Annals of the Rheumatic Diseases·Madeleine JenningKarl Skriner
Aug 23, 2020·International Journal of Environmental Research and Public Health·Alexandre BaudetCatherine Bisson
Jun 12, 2019·Scientific Reports·Jôice Dias CorrêaDana T Graves
Feb 19, 2020·Clinical and Experimental Dental Research·Hajer A AldulaijanLisa M Yerke
Jul 26, 2018·Rheumatology International·Leena ÄyräväinenMarjatta Leirisalo-Repo
Dec 12, 2020·Frontiers in Cellular and Infection Microbiology·Eun-Hye KimSemin Lee
Nov 16, 2020·Medical Hypotheses·Naglaa El-WakeelAbeer S Gawish
Dec 15, 2020·Journal of Translational Medicine·Xiaofei HuangLili Chen
Mar 19, 2019·Diabetes Research and Clinical Practice·Chien-Ying LeeKuang-Hua Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.