PMID: 9193897May 1, 1997Paper

Relationship between pituitary hormones, antioxidant enzymes, and histopathological changes in the mammary gland of senescent rats

Experimental Gerontology
A D BolzánR G Goya

Abstract

In order to assess the possible involvement of endocrine factors and antioxidant enzymes (AOE) in the mammary pathology typically observed in old female rats, we undertook to determine the relationship between pituitary hormones, AOE activity, and histopathological changes in the mammary gland of senescent rats carrying neoplastic and nonneoplastic mammary pathologies. Serum levels of several pituitary hormones were determined by RIA in young (five months) and senescent (33 months) Sprague-Dawley female rats. The activity of catalase (CAT) and superoxide dismutase (SOD) in mammary tissue from the senescent animals was also determined. Senescent rats showed higher levels of prolactin (PRL) (p < 0.01), thyroid-stimulating hormone (TSH) (p < 0.05) and follicle-stimulating hormone (FSH) (p < 0.01) than their young counterparts. In senescent females the main histopathological findings at mammary level were a marked hyperplasia and the presence of fibroadenomas. In this group there was a positive correlation between serum levels of PRL and the activity of mammary SOD (p < 0.05). There was also a positive correlation between serum levels of FSH and the activity of mammary CAT (p < 0.001). Young females, rendered moderately hyperprolac...Continue Reading

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Citations

Apr 18, 2000·Experimental Gerontology·H M Brown-Borg, S G Rakoczy
May 10, 2000·Free Radical Biology & Medicine·S J Hauck, A Bartke
Apr 11, 2008·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Chi-Feng LiuSong-Chow Lin
Oct 7, 2004·Neuropeptides·Tihomir BalogTatjana Marotti
Jan 30, 2002·Experimental Biology and Medicine·Holly M Brown-BorgMelissa A Kennedy
Mar 27, 2021·Frontiers in Neuroendocrinology·G Molina-SalinasM Cerbon
Apr 14, 2010·European Journal of Pharmacology·Nagarethinam BaskaranPachaiappan Pugalendhi

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