Relationship between plasma concentrations of beta-carotene and alpha-tocopherol and life-style factors and levels of DNA adducts in lymphocytes

Nutrition and Cancer
Y WangK Tomokuni

Abstract

beta-Carotene and alpha-tocopherol have been thought to reduce risk of lung cancer. Whether beta-carotene and alpha-tocopherol influence human DNA adducts, indicators of biologically effective doses of carcinogens, has been seldom studied. In this cross-sectional study, we measured plasma beta-carotene and alpha-tocopherol in 192 healthy men and DNA adducts in lymphocytes in 104 of the subjects. Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. In multiple regression analysis, parameters such as alcohol consumed per day, high-density lipoprotein cholesterol, Quetelet index, and cigarettes smoked per day were correlated inversely, whereas age, plasma alpha-tocopherol, and intake frequency of fruits were correlated positively with plasma beta-carotene concentration. DNA adduct levels of high plasma beta-carotene or alpha-tocopherol groups were not significantly different from the DNA adduct levels of low plasma beta-carotene or alpha-tocopherol groups among current smokers o...Continue Reading

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Citations

Jul 1, 1999·Molecular Aspects of Medicine·A R Collins
Aug 31, 1999·The Proceedings of the Nutrition Society·P A Morrissey, P J Sheehy
Jun 18, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J S MandevilleH A Tajmir-Riahi
Jun 22, 2000·Toxicologic Pathology·A C Povey
Sep 19, 2002·Nutrition and Cancer·Arsalan S HaqqaniH Chaim Birnboim
Jan 1, 1998·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Ichiba
Apr 21, 2007·Journal of Gastroenterology and Hepatology·Francesco MarottaLester Packer
Dec 1, 1999·Nutrition and Cancer·R W WelchJ J Strain
Jul 3, 1999·Nutrition Reviews·D A CooperJ C Peters
Aug 18, 2004·Cancer Research·Vasundara VenkateswaranLaurence H Klotz

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