Relationship Between Plasma Copper Concentration and Body Fat Distribution in Children in China: a Cross-Sectional Study.

Biological Trace Element Research
Jingjing LiangZheqing Zhang

Abstract

This study aimed to explore the association of the plasma copper concentration with body fat distribution and the potential mediating effect of inflammation status in children. A total of 454 children were recruited in this study. Dual-energy X-ray absorptiometry was applied to measure the fat mass (FM) and fat mass percentages (FM%) at whole body, trunk, appendicular, android, and gynoid regions. Android to gynoid fat mass ratio and fat mass to lean mass (FM/LM) ratio at whole body, trunk, and appendicular sites were calculated. Plasma copper concentration was measured via inductively coupled plasma mass spectrometry. C-reactive protein (CRP) was determined by ELISA. After adjusting for covariates, multiple linear regression analyses showed that, for every additional unit increase in the plasma copper concentration, the FM, FM%, and FM/LM at whole body and subregions increased by 0.030-0.472 kg (P < 0.001-0.019), 0.013-1.04% (P = 0.007-0.042), and 0.021-0.030 (P < 0.001), respectively. Mediating analysis suggested that CRP significantly mediated 22.0-30.6% (P < 0.001) of the estimated association of copper with FM% and FM/LM at whole body and limbs. Thus, children with higher plasma levels of copper tended to have a higher reg...Continue Reading

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