Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Anita K DunbierMitch Dowsett

Abstract

PURPOSE To determine whether plasma estradiol (E2) levels are related to gene expression in estrogen receptor (ER)-positive breast cancers in postmenopausal women. Materials and METHODS Genome-wide RNA profiles were obtained from pretreatment core-cut tumor biopsies from 104 postmenopausal patients with primary ER-positive breast cancer treated with neoadjuvant anastrozole. Pretreatment plasma E2 levels were determined by highly sensitive radioimmunoassay. Genes were identified for which expression was correlated with pretreatment plasma E2 levels. Validation was performed in an independent set of 73 ER-positive breast cancers. Results The expression of many known estrogen-responsive genes and gene sets was highly significantly associated with plasma E2 levels (eg, TFF1/pS2, GREB1, PDZK1 and PGR; P < .005). Plasma E2 explained 27% of the average expression of these four average estrogen-responsive genes (ie, AvERG; r = 0.51; P < .0001), and a standardized mean of plasma E2 levels and ER transcript levels explained 37% (r, 0.61). These observations were validated in an independent set of 73 ER-positive tumors. Exploratory analysis suggested that addition of the nuclear coregulators in a multivariable analysis with ER and E2 leve...Continue Reading

References

Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A M BrownP Chambon
Oct 31, 1998·Breast Cancer Research and Treatment·W YueR J Santen
Apr 25, 2000·The Journal of Biological Chemistry·C A MolloyB R Westley
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Apr 18, 2002·Journal of the National Cancer Institute·T KeyUNKNOWN Endogenous Hormones and Breast Cancer Collaborative Group
May 23, 2002·Recent Progress in Hormone Research·Evan R Simpson, Mitch Dowsett
May 20, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W R MillerT J Anderson
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators
Jun 17, 2004·Journal of the National Cancer Institute·Alison M DunningBruce A J Ponder
Jan 12, 2005·Breast Cancer Research : BCR·Mitch Dowsett, Elizabeth Folkerd
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitch DowsettIan E Smith
Jun 30, 2005·Breast Cancer Research and Treatment·James M RaeMarc E Lippman
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Jan 18, 2007·Journal of the National Cancer Institute·Mitch DowsettUNKNOWN IMPACT Trialists Group
Jun 9, 2007·Breast Cancer Research : BCR·Alan MackayMitch Dowsett
Jul 3, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Helen AndersonMitch Dowsett
Aug 8, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian E SmithMitch Dowsett
Sep 22, 2007·Pharmacogenetics and Genomics·William R MillerJohn Michael Dixon
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William R MillerJ Michael Dixon

❮ Previous
Next ❯

Citations

Apr 7, 2011·JAMA : the Journal of the American Medical Association·Andrea Z LaCroixUNKNOWN WHI Investigators
May 2, 2013·Hormones & Cancer·Richard J SantenDaniel F Heitjan
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Elizabeth Folkerd, Mitch Dowsett
Nov 26, 1999·The Surgical Clinics of North America·C H ChaJ E Niederhuber
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S Levenson, V C Jordan
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S Levenson, V C Jordan
Apr 27, 2012·Molecular & Cellular Proteomics : MCP·Andrei P DrabovichEleftherios P Diamandis
Jul 10, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P E Lønning
Jul 23, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Richard J Santen
Sep 24, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Anne Hege StraumePer Eystein Lønning
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Claire M Perks, Jeff M P Holly
Mar 29, 2011·Steroids·Per E LønningMitch Dowsett
Jan 25, 2011·Molecular and Cellular Endocrinology·Anita K DunbierMitch Dowsett
Oct 28, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroko YamashitaUNKNOWN Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
Feb 3, 2016·International Journal of Cancer. Journal International Du Cancer·Zhensheng WangJian-Min Yuan
Nov 26, 2013·Clinical Breast Cancer·Carlo CampagnoliPatrizia Pasanisi
Jul 8, 2014·Expert Opinion on Therapeutic Targets·Kendra M Hodgkinson, Barbara C Vanderhyden
Aug 28, 2014·Steroids·Per Eystein Lønning
Feb 11, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Per Eystein LønningMitch Dowsett
Jan 8, 2014·The Breast : Official Journal of the European Society of Mastology·Serena Di CosimoDaniele Generali
Feb 14, 2013·Cell Reports·Hisham MohammedJason S Carroll
Aug 8, 2015·PloS One·Marianne Hauglid FlågengGunnar Mellgren
May 29, 2016·Molecular Diagnosis & Therapy·Josee-Lyne Ethier, Eitan Amir
Apr 14, 2016·Journal of Molecular Endocrinology·Hong ZhaoSerdar E Bulun
Jun 21, 2008·Steroids·Laurence M Demers
Apr 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth J FolkerdMitch Dowsett
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth J Folkerd, Mitch Dowsett
Dec 15, 2010·Veterinary Pathology·P Rivera, H von Euler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.