Relationship between plasma glucose levels in glucose-intolerant women and newborn macrosomia

The Journal of Maternal-fetal Medicine
A VermaN Okun

Abstract

The purpose of this study was to examine the relationship between newborn macrosomia and plasma glucose profile in both a "glucose challenge test (GCT)-positive oral glucose tolerance test (OGTT)-negative" group (n = 113) and a gestational diabetes mellitus (GDM) group (n = 50). We examined 1) plasma glucose concentrations following a positive screen 50-g GCT (n = 163), 2) glucose concentrations following a 100-g OGTT (n = 163), and 3) the average fasting (AF) and 2-hour postprandial (APP) plasma glucose concentrations in the treated GDM group (n = 46). It was a case-control study with macrosomia vs. non-macrosomia in the ratio of 1:4. Macrosomia was analyzed by both birthweight > 4,000 g and gender-specific birthweight > 90th percentile for gestational age criteria. The GCT and the OGTT were performed between 26 and 30 weeks of pregnancy. The results demonstrated no significant impact of plasma glucose values from GCT, OGTT, AF, or APP on macrosomia in both "GCT-positive OGTT-negative" and GDM (treated) groups. Further, the screening and diagnostic plasma glucose concentrations were not related to macrosomia in both "GCT-positive OGTT-negative" and GDM groups. We found a difference of 0.6 mmol/liter in the maternal AF and APP ...Continue Reading

Citations

Oct 26, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·M BonomoA Morabito
Aug 10, 2018·Biology Letters·Emilie McConnachieMarina A G von Keyserlingk
May 11, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A Weissmann-BrennerM Y Divon
Oct 14, 2003·Journal of the American Veterinary Medical Association·Nadja Wielebnowski
Sep 29, 2019·Journal of Applied Animal Welfare Science : JAAWS·Heather Browning
Oct 3, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xinyi KangJing Xiao
Jan 6, 2004·Obstetrics and Gynecology·David M StamilioGeorge A Macones

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