Relationship between plasma pyridoxal-5'-phosphate concentration and the apoenzyme content of serum aminotransferases in patients with a renal allograft

Clinica Chimica Acta; International Journal of Clinical Chemistry
J C HafkenscheidC M van Dijk

Abstract

In 76 patients with a renal allograft the plasma concentration of pyridoxal-5'-phosphate, the activity concentrations of aspartate aminotransferase and alanine aminotransferase and the percentage stimulation of both enzymes have been investigated. Generally, the concentration of the coenzyme was decreased in the patient group compared to normal individuals. The percentage increase of aspartate aminotransferase is the same for the patients as for the normal group. However, the stimulation of alanine aminotransferase is greatly increased for the patient group except for those patients who received cyclosporine A instead of azathioprine. The highly significant inverse correlation between the plasma pyridoxal-5'-phosphate concentration and the percentage stimulation of the enzymatic activity of aspartate aminotransferase and alanine aminotransferase observed before for a normal group, is not present in our patient group. The percentage increase is independent on the activity concentration of the enzymes. It is concluded that the high stimulation of alanine aminotransferase depends on the administration of azathioprine.

References

Feb 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Ratnaike, D W Moss
Mar 24, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·S B Rosalki, R A Bayoumi
Mar 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·D W Moss
Jul 15, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Cheung, M H Briggs
Apr 1, 1970·Analytical Biochemistry·B Chabner, D Livingston
Jan 1, 1966·Scandinavian Journal of Clinical and Laboratory Investigation·K Egeblad, T Astrup
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·B LacourD Durand

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Citations

May 29, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·J C HafkenscheidC M van Dijk
Jun 21, 2002·Veterinary Clinical Pathology·Tracy Stokol, Hollis Erb
Jun 21, 2002·Veterinary Clinical Pathology·Christopher I. MesherTracy Stokol
Oct 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A M Gressner, D Sittel

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