Relationship Between Polypharmacy and Quality of Life Among People in 24 Countries Living With HIV.

Preventing Chronic Disease
Chinyere OkoliDuncan Short

Abstract

People living with HIV (PLHIV) have greater risk of having multiple health conditions. We measured the relationship between increased medication and overall quality of life among PLHIV from 24 countries. We analyzed data for 2,112 adult PLHIV on antiretroviral therapy (ART) in 24 countries who completed the 2019 Positive Perspectives survey. Polypharmacy was defined as taking 5 or more pills a day or currently taking medications for 5 or more conditions. Outcomes were self-rated overall health, treatment satisfaction, and self-reported virologic control. New treatment concerns were issues not prioritized at ART initiation but now deemed paramount. Data were analyzed with descriptive and multivariable statistics. Overall prevalence of polypharmacy was 42.1%. People reporting polypharmacy had significantly poorer health outcomes independent of existing comorbidities; their odds of treatment satisfaction, optimal overall health, and virologic control were lower by 27.0% (adjusted odds ratio [AOR] = 0.73; 95% CI, 0.59-0.91), 36.0% (AOR = 0.64; 95% CI, 0.53-0.78), and 46.0% (AOR = 0.54, 95% CI, 0.42-0.70), respectively, compared with those without polypharmacy (all P < .05). Most PLHIV (56.6%) were concerned about taking more medici...Continue Reading

References

Jan 12, 2013·AIDS Patient Care and STDs·Alan T Rodriguez-PenneyUNKNOWN HIV Neurobehavioral Research Program HNRP Group
Apr 23, 2013·Journal of General Internal Medicine·Carol HoltzmanUNKNOWN , and the HOPS Investigators
Jun 7, 2013·Drugs & Aging·E Jennifer EdelmanAmy C Justice
Feb 12, 2015·Archives of public health = Archives belges de santé publique·Sophie DegrooteDominique M Vandijck
Jan 17, 2016·International Journal of Epidemiology·Catherine R LeskoUNKNOWN CNICS Investigators
Jun 24, 2016·BMC Medicine·Jeffrey V LazarusJürgen Kurt Rockstroh
Aug 16, 2016·PloS One·Adam TrickeyUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)
Sep 13, 2016·Clinical Interventions in Aging·Mercedes Gimeno-GraciaMaría José Rabanaque-Hernández
Sep 18, 2016·The Patient·Kim EnglerBertrand Lebouché
Sep 12, 2017·Journal of Psychiatric and Mental Health Nursing·E C D CastilhoA I Miasso
Oct 12, 2017·BMC Geriatrics·Nashwa MasnoonGillian E Caughey
Jun 27, 2019·BMC Infectious Diseases·Paolo MaggiGiuseppe Vittorio De Socio

❮ Previous
Next ❯

Citations

Sep 16, 2020·International Journal of STD & AIDS·Thana Khawcharoenporn, Vitsaroot Tanslaruk

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.